{"id":"W4220807055","doi":"10.1126/scitranslmed.abl7634","title":"The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Partenariat Canadien Contre Le Cancer; Universität zu Lübeck; Texas Tech University; School of Medicine, Indiana University; Indiana Clinical and Translational Sciences Institute; Johns Hopkins University; National Institute on Aging; Eli Lilly and Company; Alzheimer's Association","keywords":"Niacin; Microglia; Neuroprotection; Medicine; Amyloid (mycology); Neuroscience; Pharmacology; Immunology; Pathology; Biology; Internal medicine; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001387108,0.000126301,0.0001231136,0.000278176,0.0008364014,0.00002871159,0.0003245527,0.00001005151,0.00004285538],"category_scores_gemma":[0.0009001679,0.00009144838,0.00003014883,0.0006003508,0.001112064,0.0002768507,0.00005926623,0.0001640765,0.000001722436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002098226,"about_ca_system_score_gemma":0.0004013437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001470759,"about_ca_topic_score_gemma":0.000001684978,"domain_scores_codex":[0.9972939,0.000375878,0.0003841205,0.0004775004,0.001234839,0.0002337372],"domain_scores_gemma":[0.9989401,0.0003737618,0.000127032,0.0002374711,0.00005982291,0.0002617957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001420537,0.00005411402,0.0001760331,0.000005101562,5.252421e-7,0.000005106575,0.0004634989,0.01317887,0.9738075,0.009517689,0.00002216496,0.001348909],"study_design_scores_gemma":[0.00103503,0.0001429252,0.002410301,0.0000236603,0.00001180137,0.000003464782,0.00005644921,0.3325516,0.6598274,0.003632489,0.0001750778,0.0001297914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777418,0.0002336515,0.0003246741,0.02073598,0.000230803,0.0005494982,0.0001276893,0.00003446889,0.00002141371],"genre_scores_gemma":[0.9987893,0.00006418827,0.00022606,0.0005545029,0.00003123637,0.00008157561,0.000005411798,0.00001119349,0.0002364943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3193727,"threshold_uncertainty_score":0.6433008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05838241072246523,"score_gpt":0.3153372843990362,"score_spread":0.256954873676571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}