{"id":"W4220807299","doi":"10.1016/j.celrep.2021.110187","title":"Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of Dental and Craniofacial Research; Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft; Svenska Läkaresällskapet; Wellcome Trust","keywords":"Candida albicans; ESCRT; Hypha; Cell biology; Secretion; Biology; Exocytosis; Microbiology; Intracellular; Biochemistry; Endosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600379,0.000227531,0.0002927576,0.0003028224,0.0004434784,0.0008176063,0.0002765473,0.0005769955,0.001900464],"category_scores_gemma":[0.0002555482,0.0002041245,0.0002685425,0.0002380589,0.0001933547,0.0004861258,0.000510886,0.0005689778,0.0005769389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004464888,"about_ca_system_score_gemma":0.0005214108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009909213,"about_ca_topic_score_gemma":0.00180945,"domain_scores_codex":[0.9996635,0.00002754614,0.00002993832,0.00005550418,0.00009838186,0.0001251021],"domain_scores_gemma":[0.9998443,0.000008162214,0.00002873003,0.00001833243,0.00004171359,0.00005874233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003672848,0.00003613731,0.0007527223,0.00005097083,0.000006326484,0.0001993403,0.00003570952,0.00004679836,0.9956495,0.0001967766,0.00021299,0.002445512],"study_design_scores_gemma":[0.00006816427,0.000188159,0.08825106,0.00002525527,0.00002271052,0.0009491126,0.0001958874,0.001430458,0.9027907,0.0002491589,0.005807461,0.00002182592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890655,0.004569392,0.001758015,0.0002730889,0.0000682255,0.00004075609,0.0005160045,0.0001248743,0.003584001],"genre_scores_gemma":[0.9931425,0.0008241342,0.0007021697,0.0000804888,0.00001706533,0.00004126162,0.0004019454,0.0000201506,0.004770241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001900464,"threshold_uncertainty_score":0.00635767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04884133585911146,"score_gpt":0.2917629533704491,"score_spread":0.2429216175113376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}