{"id":"W4220807299","doi":"10.1016/j.celrep.2021.110187","title":"Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of Dental and Craniofacial Research; Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft; Svenska Läkaresällskapet; Wellcome Trust","keywords":"Candida albicans; ESCRT; Hypha; Cell biology; Secretion; Biology; Exocytosis; Microbiology; Intracellular; Biochemistry; Endosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009100886,0.0002107758,0.0004103206,0.0001032626,0.0004020315,0.00002433841,0.00007050122,0.0000831194,0.001127437],"category_scores_gemma":[0.000142183,0.0001884019,0.0001360154,0.0001563297,0.00009538905,0.00006466385,0.0002866911,0.0005969434,0.000006573643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007487555,"about_ca_system_score_gemma":0.0003136181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001152027,"about_ca_topic_score_gemma":0.0003263068,"domain_scores_codex":[0.9976118,0.0001304992,0.0005526295,0.0006742729,0.0006489213,0.0003819038],"domain_scores_gemma":[0.998758,0.00005157303,0.0002088538,0.0006248252,0.00006487851,0.0002918807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007921362,0.0005579128,0.6733239,0.0003194999,0.00006051342,0.009193036,0.0008519399,0.00001343223,0.3124514,0.00004442305,0.0004894838,0.001902288],"study_design_scores_gemma":[0.002321701,0.0008585343,0.6135239,0.0001548816,0.000288672,0.002943431,0.004901401,0.00004890437,0.3609693,0.0008059863,0.01255282,0.0006304422],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949625,0.0004575301,0.00007893782,0.0003927576,0.0003365484,0.0009552825,0.00002244422,0.00006645359,0.002727513],"genre_scores_gemma":[0.9922126,0.000116395,0.0001375417,0.0002258814,0.0001009485,0.0001613362,0.00004406474,0.00002768177,0.006973577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05980003,"threshold_uncertainty_score":0.9997857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04884133585911146,"score_gpt":0.2917629533704491,"score_spread":0.2429216175113376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}