{"id":"W4220811291","doi":"10.3390/cancers14061592","title":"Targeting an MDM2/MYC Axis to Overcome Drug Resistance in Multiple Myeloma","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Mdm2; Bortezomib; Chromatin immunoprecipitation; Cancer research; Transfection; Molecular biology; Oncogene; Biology; Cell culture; Viability assay; XIAP; Cell cycle; Apoptosis; Chemistry; Multiple myeloma; Gene expression; Gene; Programmed cell death; Immunology; Genetics; Caspase; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001677434,0.0004041136,0.0003828211,0.0003015013,0.0001533425,0.0003308986,0.0002479623,0.0002656712,0.001538642],"category_scores_gemma":[0.00006459325,0.00009420642,0.0002396233,0.0002263882,0.0001483873,0.0001893237,0.0002687974,0.0007396198,0.0003225865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003224174,"about_ca_system_score_gemma":0.000201402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001457165,"about_ca_topic_score_gemma":0.0004446893,"domain_scores_codex":[0.9999024,0.0000101968,0.000008177234,0.00002023169,0.00003106694,0.00002789112],"domain_scores_gemma":[0.9999597,0.000005256043,0.00001154645,0.000004117077,0.00000623405,0.00001314567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001880206,0.0001144714,0.0004076126,0.0001636633,0.00002172468,0.00006682474,0.00001200714,0.0002523001,0.9887312,0.000206222,0.0003489721,0.00948704],"study_design_scores_gemma":[0.0001172968,0.001435999,0.005563833,0.0000276582,0.00009873969,0.0006250631,0.00003617258,0.002657803,0.9652556,0.0002077546,0.02396328,0.00001093847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9630563,0.01810106,0.01212781,0.0006631621,0.0002339529,0.000208393,0.001302574,0.0006974665,0.003609351],"genre_scores_gemma":[0.9871756,0.00485132,0.004553073,0.0001562075,0.00004743653,0.0001326832,0.0008331216,0.00003766399,0.002212864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001538642,"threshold_uncertainty_score":0.005147219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02718241795215181,"score_gpt":0.3077250464057237,"score_spread":0.2805426284535719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}