{"id":"W4220813557","doi":"10.1128/jb.00623-21","title":"Exploratory Growth in Streptomyces venezuelae Involves a Unique Transcriptional Program, Enhanced Oxidative Stress Response, and Profound Acceleration in Response to Glycerol","year":2022,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Deutsche Forschungsgemeinschaft; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Biology; Streptomyces; Transcriptome; Sigma factor; Gene expression; Regulation of gene expression; Transcription factor; Gene; Genetics; Cell biology; Bacteria; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005995593,0.0003995106,0.0002021235,0.0002777533,0.0002583616,0.000336221,0.00007990988,0.000103612,0.0006682503],"category_scores_gemma":[0.0001021178,0.00007965933,0.0002072065,0.0002109991,0.0002311238,0.0001677924,0.0003981214,0.0003613113,0.0001215233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002031982,"about_ca_system_score_gemma":0.0002928198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001765411,"about_ca_topic_score_gemma":0.003684975,"domain_scores_codex":[0.9999219,0.000008247796,0.000004391427,0.0000234279,0.00001624398,0.00002580822],"domain_scores_gemma":[0.999936,0.00001095944,0.0000180774,0.000006043263,0.000007526616,0.00002136503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001595441,0.00002719362,0.002862705,0.0000349793,0.000003031723,0.00006344875,0.00004707652,0.00004448961,0.994089,0.00006788827,0.00001935317,0.002581361],"study_design_scores_gemma":[0.00001924177,0.00096935,0.3531268,0.00003186343,0.00004536219,0.0008228564,0.000792372,0.001395148,0.6384078,0.0005259676,0.003816262,0.00004695347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969149,0.0004163313,0.0009211085,0.00004095175,0.00001241132,0.00001222237,0.0004338448,0.00003509734,0.001213207],"genre_scores_gemma":[0.9960088,0.0002473547,0.001189002,0.00002665628,0.000007997472,0.00001605423,0.000780071,0.00001020939,0.001713915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001765411,"threshold_uncertainty_score":0.003510296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02186309373354758,"score_gpt":0.2824374957701797,"score_spread":0.2605744020366322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}