{"id":"W4220817846","doi":"10.1016/j.ijrobp.2021.12.018","title":"A Clinically Translatable, Extensively Validated Immune-based Classification of Human Papillomavirus-Associated Head and Neck Cancer With Implications for Treatment Deintensification and Immunotherapy","year":2022,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Calgary; McGill University; University of British Columbia; Vancouver General Hospital; Western University","funders":"","keywords":"Medicine; Oncology; Internal medicine; Head and neck squamous-cell carcinoma; Cohort; Head and neck cancer; Prospective cohort study; Retrospective cohort study; Cancer; Proportional hazards model; Immune system; Immunotherapy; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003616742,0.0004599712,0.0006329794,0.001767816,0.0006534362,0.001994674,0.0008005808,0.0009174437,0.002931449],"category_scores_gemma":[0.01043487,0.0001433466,0.0005948911,0.0009534504,0.0007127621,0.0008630136,0.00136778,0.0008288062,0.00130474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009194166,"about_ca_system_score_gemma":0.001151863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001488953,"about_ca_topic_score_gemma":0.002133186,"domain_scores_codex":[0.9982369,0.0004390477,0.0001948103,0.0004141765,0.0004629179,0.0002521928],"domain_scores_gemma":[0.9958402,0.001112059,0.0007760496,0.0004682328,0.001578843,0.0002246674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001425249,0.0004173241,0.7563845,0.0004280173,0.0003110331,0.0003597797,0.0004184417,0.002654161,0.04499774,0.002123702,0.00836884,0.1821112],"study_design_scores_gemma":[0.000176681,0.001634283,0.9216782,0.0002192592,0.0005657375,0.003278704,0.0008138346,0.01577281,0.02899296,0.004748692,0.02204401,0.00007491317],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9502805,0.002507068,0.02261992,0.001136078,0.0004733907,0.0007487747,0.00499887,0.0003477999,0.01688752],"genre_scores_gemma":[0.9818395,0.0002636977,0.01251539,0.0003923627,0.0001266358,0.0002193072,0.003144959,0.00006572111,0.001432544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003616742,"threshold_uncertainty_score":0.01912737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04420443665013479,"score_gpt":0.3855221533133001,"score_spread":0.3413177166631653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}