{"id":"W4220819700","doi":"10.1002/em.22479","title":"<scp>AOP</scp> report: Development of an adverse outcome pathway for oxidative <scp>DNA</scp> damage leading to mutations and chromosomal aberrations","year":2022,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Ottawa; Health Canada","funders":"Health Canada; Natural Sciences and Engineering Research Council of Canada; Health and Environmental Sciences Institute","keywords":"Genotoxicity; DNA damage; Adverse Outcome Pathway; DNA repair; Biology; Base excision repair; Computational biology; Genetics; DNA; Chemistry; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007384599,0.001393025,0.0006350251,0.003703753,0.001651743,0.002689742,0.002711002,0.004305381,0.0422994],"category_scores_gemma":[0.01340806,0.0004865248,0.00127223,0.001751294,0.001260056,0.00189944,0.0023264,0.002897772,0.01766567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002943994,"about_ca_system_score_gemma":0.007721028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01095262,"about_ca_topic_score_gemma":0.01463646,"domain_scores_codex":[0.9937245,0.001064435,0.0004203228,0.0004267441,0.003982238,0.00038177],"domain_scores_gemma":[0.9790872,0.00389135,0.002630082,0.001583082,0.01091848,0.001889829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004014912,0.0004174119,0.004214425,0.001403452,0.00009690649,0.001337415,0.0001365209,0.003276335,0.01364214,0.0104924,0.9072271,0.05735459],"study_design_scores_gemma":[0.0001379288,0.0009768944,0.007029479,0.0005057692,0.000100511,0.0007773707,0.0001450146,0.003523889,0.04112965,0.009731294,0.935834,0.0001082652],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"other","genre_gemma":"methods","genre_scores_codex":[0.03443205,0.01197016,0.120796,0.1606436,0.04010868,0.01344516,0.1230353,0.01186643,0.4837028],"genre_scores_gemma":[0.1692388,0.02939168,0.1159568,0.05621716,0.0201475,0.006608685,0.1431175,0.004017674,0.4553043],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0422994,"threshold_uncertainty_score":0.1415055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122451912566868,"score_gpt":0.2494714012561772,"score_spread":0.2382468821305085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}