{"id":"W4220821020","doi":"10.1101/2022.03.08.483464","title":"Remodeled Connexin 43 hemichannels alter cardiac excitability and promote arrhythmias","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; York University; American Heart Association","keywords":"Connexin; Gap junction; Cardiomyopathy; Heart failure; Cardiac function curve; Internal medicine; Medicine; Depolarization; Cardiology; Intercalated disc; Sudden cardiac death; Agonist; Endocrinology; Cell biology; Biology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001493675,0.0003946202,0.000322395,0.0002263478,0.0001740156,0.0002597497,0.0001926809,0.0004977661,0.001416757],"category_scores_gemma":[0.00009222296,0.0001665421,0.0004592963,0.000122427,0.0003525779,0.0002871315,0.000259967,0.0008376788,0.0002214793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001784815,"about_ca_system_score_gemma":0.0001049888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002360417,"about_ca_topic_score_gemma":0.0003845083,"domain_scores_codex":[0.9998581,0.00001773247,0.00002146516,0.00003337613,0.0000296207,0.00003959411],"domain_scores_gemma":[0.9998007,0.00002341075,0.00006476298,0.00001950272,0.00001543224,0.00007630093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001439975,0.00002929946,0.0001745557,0.00001823897,0.000003823395,0.0000437885,0.000008783119,0.00001788733,0.9992234,0.00003865645,0.00001707929,0.0002805281],"study_design_scores_gemma":[0.00004206818,0.001150856,0.01596475,0.00001420598,0.00003357668,0.0003809209,0.0000642811,0.0008188598,0.9805449,0.0001394779,0.0008374451,0.000008712063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975655,0.0005795876,0.001116171,0.00007628107,0.00003113832,0.00001646963,0.0001857661,0.00005010972,0.0003789502],"genre_scores_gemma":[0.9972289,0.0004609778,0.0009596371,0.0000933096,0.00001406855,0.00003522336,0.0001508421,0.00001717091,0.001039973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001416757,"threshold_uncertainty_score":0.004739463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134662976045531,"score_gpt":0.2244441023319908,"score_spread":0.2130974725715355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}