{"id":"W4220825668","doi":"10.4049/jimmunol.2100049","title":"An Epidemic Zika Virus Isolate Drives Enhanced T Follicular Helper Cell and B Cell–Mediated Immunity","year":2022,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Cancer Institute; Public Health Agency of Canada; Government of Canada; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Universidade Federal de Minas Gerais; National Institute of General Medical Sciences; Public Health Agency","keywords":"Zika virus; Germinal center; Virology; Biology; Immunity; T cell; Virus; T helper cell; Vaccination; Immunology; B cell; Avidity; Follicular phase; Immune system; Antibody; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104649,0.0002233295,0.0001561837,0.0001505587,0.000122664,0.0003012777,0.0001108986,0.0001850162,0.001204045],"category_scores_gemma":[0.000134373,0.000109027,0.00009680216,0.00006458426,0.000189034,0.000131345,0.0001791425,0.0006681045,0.000168387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002664695,"about_ca_system_score_gemma":0.0001141017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009176986,"about_ca_topic_score_gemma":0.00119916,"domain_scores_codex":[0.9998956,0.00001601709,0.000006457482,0.00002143421,0.000016897,0.00004355798],"domain_scores_gemma":[0.9998958,0.00001921875,0.00002351274,0.0000107987,0.00001492193,0.00003583194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000923285,0.00003785882,0.001050706,0.00001834971,0.000001827372,0.00003523207,0.00002055557,0.00001060268,0.9981665,0.00002801599,0.00002285521,0.0005151996],"study_design_scores_gemma":[0.0001524672,0.002897462,0.2851569,0.00004227108,0.00005200116,0.001525797,0.0007395569,0.001975662,0.7026311,0.0002235191,0.004584144,0.00001922147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988682,0.0002191297,0.0001525803,0.00002405938,0.000007049149,0.000007811393,0.00007776433,0.00001255668,0.0006309561],"genre_scores_gemma":[0.9989678,0.0001285249,0.000189767,0.00003249439,0.00000570344,0.000005548256,0.0001256135,0.000004482286,0.0005401387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001204045,"threshold_uncertainty_score":0.004027903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006616134252828946,"score_gpt":0.2431298292439811,"score_spread":0.2365136949911522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}