{"id":"W4220826638","doi":"10.1007/s00415-022-11068-0","title":"Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations","year":2022,"lang":"en","type":"article","venue":"Journal of Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Université Laval; Health Sciences Centre; Occupational Cancer Research Centre; Montreal Neurological Institute and Hospital; University of Toronto; Western University; Sunnybrook Health Science Centre","funders":"NIHR Cambridge Biomedical Research Centre; UCLH Biomedical Research Centre; Department of Health and Social Care; Medical Research Council; UK Dementia Research Institute; Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; Universiteit Antwerpen; University of Toronto; Universidade de Coimbra; Università degli Studi di Firenze; Alzheimer’s Research UK; Toronto Rehabilitation Institute; Robarts Research Institute; Alzheimer's Society; Agence Nationale de la Recherche; University of Oxford; Erasmus Medisch Centrum; University Health Network; Brain Research UK; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; Karolinska Institutet; EU Joint Programme – Neurodegenerative Disease Research; Sunnybrook Research Institute; National Brain Appeal","keywords":"Frontotemporal dementia; C9orf72; Psychology; Frontotemporal lobar degeneration; Dementia; Mutation; Neuroscience; Audiology; Medicine; Internal medicine; Genetics; Disease; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004271116,0.00008877536,0.0003327026,0.0003297229,0.00006546294,0.00001251412,0.0002233198,0.00004766605,0.002138328],"category_scores_gemma":[0.0001224756,0.00007582364,0.00009519277,0.0002335334,0.00004216316,0.00007266402,0.0002206373,0.000675398,0.00002142872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009253735,"about_ca_system_score_gemma":0.0001897542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007445793,"about_ca_topic_score_gemma":0.00002052164,"domain_scores_codex":[0.9981414,0.00030531,0.0005732276,0.0001577869,0.0005280427,0.0002942223],"domain_scores_gemma":[0.9992388,0.0001043444,0.0001576351,0.0001752802,0.0001031921,0.0002207083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009207179,0.002161212,0.8163709,0.0000939688,0.00060253,0.01246218,0.004783289,0.009703002,0.05407671,0.0001795444,0.08272086,0.007638596],"study_design_scores_gemma":[0.001810121,0.003905816,0.9783449,0.000009465492,0.00004311291,0.001595343,0.00002771265,0.001920664,0.0000690571,0.0004118928,0.0118016,0.0000603326],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9331223,0.00008574977,0.0002660187,0.06576588,0.0001911899,0.0002982523,0.00000564842,0.000006554324,0.000258385],"genre_scores_gemma":[0.9942355,0.000007957792,0.001054291,0.004269068,0.0001543188,0.00002482435,0.000002150939,0.00001630447,0.0002355856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.161974,"threshold_uncertainty_score":0.9987739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02405959656584731,"score_gpt":0.3151437650938767,"score_spread":0.2910841685280294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}