{"id":"W4220828723","doi":"10.1002/jssc.202100979","title":"Unique green chromatography method for the determination of serotonin receptor antagonist (Ondansetron hydrochloride) related substances in a liquid formulation, robustness by quality by design‐based design of experiments approach","year":2022,"lang":"en","type":"article","venue":"Journal of Separation Science","topic":"Analytical Methods in Pharmaceuticals","field":"Chemistry","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas College","funders":"","keywords":"Chromatography; Chemistry; Analyte; High-performance liquid chromatography; Detection limit; Correlation coefficient; Impurity; Analytical Chemistry (journal); Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003587689,0.001081793,0.001050855,0.00110546,0.0004491283,0.0007249173,0.0007102035,0.0007770734,0.0007034856],"category_scores_gemma":[0.001743481,0.0004445354,0.0009046122,0.0005186702,0.000529203,0.0003924935,0.0005944921,0.0009281457,0.0002842043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008249784,"about_ca_system_score_gemma":0.001518214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006975742,"about_ca_topic_score_gemma":0.001623841,"domain_scores_codex":[0.9967578,0.0007179256,0.0002160036,0.0006074549,0.0015534,0.0001474763],"domain_scores_gemma":[0.9989104,0.0001942388,0.0003120176,0.0001005492,0.0004234526,0.00005936345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002989269,0.0002514954,0.0008010131,0.0003624094,0.0001258,0.00006496807,0.00004696817,0.001161054,0.9686015,0.0005441344,0.0003179588,0.02742384],"study_design_scores_gemma":[0.0001489701,0.003372278,0.004747545,0.00003526631,0.0003649135,0.000615885,0.00002954253,0.01377225,0.9656002,0.0003698524,0.01085338,0.00009004313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1919653,0.003764847,0.7964622,0.0002701024,0.0003135795,0.00170318,0.0008714165,0.001657229,0.002992299],"genre_scores_gemma":[0.3603635,0.002357583,0.628686,0.0004722736,0.00007149277,0.002971111,0.0009797153,0.0001524916,0.003946005],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003587689,"threshold_uncertainty_score":0.01897377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09879268509170959,"score_gpt":0.44322658204055,"score_spread":0.3444338969488405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}