{"id":"W4220832512","doi":"10.3390/v14030609","title":"Gene-Edited Cell Models to Study Chronic Wasting Disease","year":2022,"lang":"en","type":"review","venue":"Viruses","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency; University of Calgary","funders":"Alberta Innovates; Alberta Innovates - Technology Futures; Genome Canada","keywords":"Chronic wasting disease; Biology; CRISPR; Computational biology; Gene; Genome editing; Cas9; Gene isoform; Transgene; Disease; Virology; Genetics; Prion protein; Medicine; Scrapie","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005752962,0.0006951516,0.0008233791,0.0006515259,0.0001997065,0.0008518598,0.0005668336,0.0008766556,0.002383771],"category_scores_gemma":[0.0002842103,0.0001640049,0.0004412487,0.0005002999,0.0003872273,0.0006108598,0.000413904,0.001446245,0.001727631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003916354,"about_ca_system_score_gemma":0.000355541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003574656,"about_ca_topic_score_gemma":0.0005909067,"domain_scores_codex":[0.99971,0.00004758479,0.00003173712,0.00007267733,0.0001133883,0.00002466055],"domain_scores_gemma":[0.9998146,0.00005743685,0.00004359339,0.000020577,0.00003874256,0.00002502811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003057982,0.0002503631,0.0008474723,0.00532947,0.0001785637,0.001100291,0.0001842758,0.0006449437,0.8430362,0.01077662,0.01694769,0.1203982],"study_design_scores_gemma":[0.00009605227,0.001464113,0.002965407,0.0007814902,0.0004608482,0.00837943,0.0001308962,0.001218569,0.2488452,0.003954661,0.7316226,0.00008078097],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06599016,0.8017624,0.08259504,0.002263408,0.00300148,0.0006304343,0.004400366,0.001473587,0.03788321],"genre_scores_gemma":[0.2256113,0.6650601,0.05092498,0.002462186,0.0007505143,0.001029721,0.01113393,0.0003744916,0.04265277],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002383771,"threshold_uncertainty_score":0.007974505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1004166802965591,"score_gpt":0.3458181523213757,"score_spread":0.2454014720248166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}