{"id":"W4220833254","doi":"","title":"JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency","year":2022,"lang":"en","type":"article","venue":"Digital Commons@Becker (Washington University School of Medicine)","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Yale University; American Heart Association; Canadian Institutes of Health Research; March of Dimes Foundation","keywords":"Elastin; Supravalvular aortic stenosis; JAG1; Notch signaling pathway; Aorta; Tropoelastin; Cell biology; Medicine; Internal medicine; Pathology; Biology; Endocrinology; Stenosis; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002944318,0.0001366739,0.0001923624,0.0002909779,0.000175281,0.00002118893,0.0002881559,0.00006536859,0.00008064579],"category_scores_gemma":[0.0008151709,0.0001521098,0.00004366612,0.0004977522,0.0002007188,0.00005120809,0.0004474779,0.0002564943,0.000002183012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001023147,"about_ca_system_score_gemma":0.0001192928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002368109,"about_ca_topic_score_gemma":0.00007968974,"domain_scores_codex":[0.9987291,0.0001581693,0.0001927054,0.0003442744,0.0003660884,0.0002096298],"domain_scores_gemma":[0.9993438,0.00007261321,0.0001125905,0.0002484429,0.0001218216,0.0001007562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005507207,0.0005847698,0.846109,0.0001358006,0.00007398401,0.00002043693,0.001105087,0.0002846697,0.1374972,0.000486762,0.001259828,0.01189175],"study_design_scores_gemma":[0.007720632,0.003279529,0.9293076,0.0002484034,0.00008336821,0.00002633344,0.02627134,0.001169743,0.01351799,0.0005932336,0.01694253,0.0008393159],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947054,0.0002122371,0.0006173294,0.0009551626,0.00003341258,0.0003102379,0.0000245806,0.00001386218,0.003127815],"genre_scores_gemma":[0.9992575,0.00003097467,0.00004161575,0.00004881987,0.0000187866,0.000003219861,0.0002104458,0.00001458217,0.0003740534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1239792,"threshold_uncertainty_score":0.6202858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01419258678308782,"score_gpt":0.2360667912002112,"score_spread":0.2218742044171233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}