{"id":"W4220833409","doi":"10.3390/curroncol29030158","title":"Novel, First-in-Human, Oral PCLX-001 Treatment in a Patient with Relapsed Diffuse Large B-Cell Lymphoma","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta; Alberta Cancer Foundation","keywords":"Medicine; Pharmacokinetics; Pharmacodynamics; Dosing; Lymphoma; Pharmacology; Diffuse large B-cell lymphoma; Refractory (planetary science); Clinical trial; Internal medicine; Oncology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003377942,0.0004913969,0.000885386,0.0002585832,0.000441381,0.0005134568,0.0004732131,0.0009174083,0.0008788384],"category_scores_gemma":[0.0004018879,0.000208164,0.0003847206,0.0002041759,0.0003548304,0.0004936083,0.000243817,0.001334011,0.0003899725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005481351,"about_ca_system_score_gemma":0.0003900052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005075916,"about_ca_topic_score_gemma":0.001444268,"domain_scores_codex":[0.9998651,0.00004044206,0.00001480495,0.00002695096,0.00001762278,0.00003516778],"domain_scores_gemma":[0.9998034,0.00003800605,0.00002037645,0.00002152461,0.000009463206,0.0001073147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.04727071,0.02234689,0.0312652,0.001036548,0.0005248272,0.06331102,0.002153344,0.006822319,0.2973304,0.001715804,0.008859578,0.5173634],"study_design_scores_gemma":[0.05174163,0.4320597,0.1322398,0.0002066293,0.0008359235,0.1223721,0.0006610738,0.01728347,0.1755832,0.001904605,0.06478318,0.0003286847],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992346,0.002205546,0.00114251,0.001379836,0.00006954599,0.0003416815,0.000215347,0.0001285763,0.002170818],"genre_scores_gemma":[0.9943467,0.001445569,0.00127407,0.0007646721,0.00007093327,0.0001324149,0.0004245368,0.00001954022,0.001521654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009174083,"threshold_uncertainty_score":0.00397706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03539812798177847,"score_gpt":0.3017143775545909,"score_spread":0.2663162495728124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}