{"id":"W4220835467","doi":"10.1164/rccm.202109-2182le","title":"BET Protein Inhibition for Pulmonary Arterial Hypertension: A Pilot Clinical Trial","year":2022,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Resverlogix (Canada); University of Calgary; Université Laval","funders":"","keywords":"Clinical trial; Respiratory disease; Intensive care; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001075384,0.001657976,0.002429244,0.0002737397,0.0004060061,0.001176825,0.0006793041,0.001677757,0.00435572],"category_scores_gemma":[0.0005713581,0.0003567096,0.001495754,0.0003277999,0.001076747,0.0008770328,0.0003206197,0.004313213,0.0008651636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005779364,"about_ca_system_score_gemma":0.000794646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006286738,"about_ca_topic_score_gemma":0.00144549,"domain_scores_codex":[0.999737,0.000076466,0.00001221874,0.00004052606,0.00002407914,0.0001096253],"domain_scores_gemma":[0.999543,0.0001103729,0.00005522385,0.00002731829,0.00002358852,0.0002405823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7955171,0.03599102,0.001568517,0.001542413,0.002195066,0.0005575558,0.000162811,0.001611532,0.06518084,0.000905279,0.006356915,0.08841095],"study_design_scores_gemma":[0.7137687,0.2664,0.005702081,0.0001066949,0.0009743186,0.0003111921,0.00007084422,0.000810804,0.005577941,0.0003805083,0.005854513,0.00004250218],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756377,0.01370486,0.001187643,0.002474819,0.0007725082,0.001600862,0.0009704331,0.0001708852,0.003480364],"genre_scores_gemma":[0.9763669,0.0104218,0.001281647,0.002144642,0.0007800129,0.002188003,0.001513767,0.00003275828,0.0052703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00435572,"threshold_uncertainty_score":0.01457137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0486606451420263,"score_gpt":0.3439364859105164,"score_spread":0.2952758407684901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}