{"id":"W4220840510","doi":"10.1158/1538-7445.sabcs21-p1-18-08","title":"Abstract P1-18-08: Effect of duration of prior cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) therapy (≤6 mo or &amp;gt;6 mo) on alpelisib benefit in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), <i>PIK3CA</i>-mutated advanced breast cancer (ABC) from BYLieve","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Medicine; Fulvestrant; Letrozole; Internal medicine; Cohort; Population; Aromatase inhibitor; Oncology; Gastroenterology; Cancer; Breast cancer; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006003192,0.0005198083,0.0009550806,0.0001792254,0.0001771982,0.0006753301,0.0005031711,0.0006261843,0.007215173],"category_scores_gemma":[0.0007726005,0.0001797062,0.0009414842,0.0001798034,0.0004281444,0.0005685859,0.0002806294,0.002568584,0.0008925322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004121918,"about_ca_system_score_gemma":0.0009066132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005707597,"about_ca_topic_score_gemma":0.001390266,"domain_scores_codex":[0.9997798,0.00008142411,0.00001604575,0.00005216323,0.00001946205,0.00005117338],"domain_scores_gemma":[0.9992188,0.0001792639,0.0001093601,0.00004274104,0.0000397954,0.0004100732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.818259,0.02746733,0.01045787,0.0004893389,0.0008990055,0.0001204194,0.0001304891,0.00102576,0.02533609,0.0002107465,0.00516017,0.1104439],"study_design_scores_gemma":[0.1713847,0.7648894,0.04241708,0.00008802688,0.001012079,0.0004582876,0.00009237965,0.001689033,0.00957274,0.0003181072,0.008033343,0.00004486648],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960226,0.001141016,0.0001306836,0.0003037438,0.00008122245,0.0002304629,0.0007966849,0.00003449285,0.001259205],"genre_scores_gemma":[0.9934521,0.0007913048,0.0005479693,0.0005020202,0.0001534158,0.0003816325,0.001704664,0.0000244926,0.002442482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007215173,"threshold_uncertainty_score":0.02413714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02884372076074236,"score_gpt":0.3474767940793632,"score_spread":0.3186330733186208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}