{"id":"W4220840510","doi":"10.1158/1538-7445.sabcs21-p1-18-08","title":"Abstract P1-18-08: Effect of duration of prior cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) therapy (≤6 mo or &amp;gt;6 mo) on alpelisib benefit in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), <i>PIK3CA</i>-mutated advanced breast cancer (ABC) from BYLieve","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Medicine; Fulvestrant; Letrozole; Internal medicine; Cohort; Population; Aromatase inhibitor; Oncology; Gastroenterology; Cancer; Breast cancer; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008640073,0.0007724357,0.001487732,0.0007269929,0.0004552514,0.00004119932,0.0005608839,0.0002386338,0.004353371],"category_scores_gemma":[0.0002369787,0.0005998733,0.0002111519,0.001587982,0.0006335179,0.0005671212,0.0002456738,0.001775012,0.00001709773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003224015,"about_ca_system_score_gemma":0.0006785427,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008841119,"about_ca_topic_score_gemma":0.001021408,"domain_scores_codex":[0.9924237,0.0008482306,0.001296995,0.001390244,0.002928457,0.00111237],"domain_scores_gemma":[0.995212,0.001180612,0.0009380499,0.0006875123,0.001591044,0.000390831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1922168,0.002290549,0.04547438,0.0003111027,0.0008240541,0.00003379369,0.004512814,0.001719653,0.6236684,0.00001338198,0.0003052111,0.1286299],"study_design_scores_gemma":[0.02939192,0.00757267,0.5289239,0.001309024,0.00005871015,0.000003480629,0.0005460039,0.00001623729,0.4312969,0.0000604436,0.0002091306,0.0006116236],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843286,0.001461544,0.00001329862,0.0005377414,0.0002515395,0.004837456,0.008405619,0.00007829031,0.00008595612],"genre_scores_gemma":[0.9946194,0.0009080468,0.0002925384,0.0001361031,0.0003130959,0.002458791,0.0008020615,0.000223303,0.0002466306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4834495,"threshold_uncertainty_score":0.9996453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02884372076074236,"score_gpt":0.3474767940793632,"score_spread":0.3186330733186208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}