{"id":"W4220844669","doi":"10.1016/j.addr.2022.114238","title":"Why nanoparticles prefer liver macrophage cell uptake in vivo","year":2022,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":248,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"In vivo; Nanoparticle; Macrophage; Cell; Chemistry; Nanotechnology; Cell biology; In vitro; Biology; Materials science; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow","insufficient_payload"],"category_scores_codex":[0.00238894,0.00146916,0.004411933,0.000498383,0.0003473643,0.0001783194,0.001949529,0.0002804264,0.01346871],"category_scores_gemma":[0.0002590614,0.001275293,0.001228477,0.001689803,0.0002147608,0.00103867,0.001052781,0.001060856,0.005467326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001022434,"about_ca_system_score_gemma":0.0004582208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001573364,"about_ca_topic_score_gemma":0.0002143671,"domain_scores_codex":[0.9893587,0.002539776,0.003276248,0.002163733,0.00093472,0.001726845],"domain_scores_gemma":[0.9947565,0.0008293462,0.001573987,0.002285691,0.00009258819,0.0004619393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004960506,0.0005509641,0.000001507154,0.01714671,0.00002033898,0.0005398736,0.0002035715,0.0001163862,0.01726595,0.00002090938,0.01839866,0.9456855],"study_design_scores_gemma":[0.0006334607,0.00008586673,2.886319e-7,0.005799578,0.0005161743,0.00004320819,0.00004144475,0.00002500323,0.01053974,0.00002139393,0.9810148,0.001279073],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006030416,0.9869784,0.000009060694,0.00001852945,0.001313477,0.004279414,0.0003624677,0.0002488905,0.0007593653],"genre_scores_gemma":[0.00003479607,0.9922861,0.002317051,0.001024976,0.000165876,0.002395088,0.00007969145,0.0002531835,0.0014432],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9626161,"threshold_uncertainty_score":0.9998058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04283671476951274,"score_gpt":0.2867482085531145,"score_spread":0.2439114937836018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}