{"id":"W4220844669","doi":"10.1016/j.addr.2022.114238","title":"Why nanoparticles prefer liver macrophage cell uptake in vivo","year":2022,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":248,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"In vivo; Nanoparticle; Macrophage; Cell; Chemistry; Nanotechnology; Cell biology; In vitro; Biology; Materials science; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004034967,0.0005250023,0.0006285416,0.0003645442,0.0001294103,0.000764614,0.0003767708,0.001193433,0.001765881],"category_scores_gemma":[0.0003505432,0.0002170327,0.0002795268,0.0003394574,0.0004517968,0.0009772382,0.0002848553,0.001264038,0.00146585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000534241,"about_ca_system_score_gemma":0.0005309537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009089928,"about_ca_topic_score_gemma":0.001336875,"domain_scores_codex":[0.9998587,0.00002692923,0.00001145249,0.00003689439,0.00004352822,0.00002243613],"domain_scores_gemma":[0.9998901,0.00005057858,0.0000147287,0.000004186445,0.00003576653,0.000004548865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002469916,0.0000647581,0.0001891866,0.0210631,0.00008582606,0.0002842511,0.0001017852,0.0004612776,0.1412618,0.01452185,0.027985,0.7937343],"study_design_scores_gemma":[0.00004606782,0.0002264313,0.0009927592,0.002198227,0.000158929,0.001620219,0.00009713924,0.0003756061,0.04987855,0.005714324,0.9386514,0.00004033502],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009115895,0.9935651,0.001227822,0.001080518,0.0004009569,0.000009182941,0.00002329568,0.00001782662,0.002763685],"genre_scores_gemma":[0.007736517,0.9859066,0.001229026,0.001200879,0.0002787925,0.00002521951,0.00004135457,0.00001114546,0.003570407],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001765881,"threshold_uncertainty_score":0.005907476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04283671476951274,"score_gpt":0.2867482085531145,"score_spread":0.2439114937836018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}