{"id":"W4220848364","doi":"10.1101/2022.03.06.483188","title":"PTEN is required for human Treg suppression of costimulation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; BC Children's Hospital","keywords":"PTEN; PI3K/AKT/mTOR pathway; FOXP3; Biology; Cancer research; Immunology; Protein kinase B; Function (biology); Phenotype; Immune system; Signal transduction; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002289498,0.0003456794,0.0002319406,0.0003613413,0.0001866405,0.0004565707,0.0002170631,0.0002215203,0.002927914],"category_scores_gemma":[0.0002600143,0.0001357864,0.000227677,0.0002038349,0.0002470832,0.0001169152,0.0002886034,0.0003222696,0.001207709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001876301,"about_ca_system_score_gemma":0.0002988281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007036417,"about_ca_topic_score_gemma":0.0006254525,"domain_scores_codex":[0.9997084,0.00004334228,0.00002429249,0.00004754189,0.000113306,0.00006303361],"domain_scores_gemma":[0.9997943,0.00004431904,0.00005459825,0.00003692285,0.00001810991,0.0000517659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000124584,0.00001416775,0.0003089416,0.00002198299,0.000005220372,0.0001789866,0.0000104402,0.00009831237,0.9973752,0.0003206381,0.00009891586,0.001442557],"study_design_scores_gemma":[0.00001636547,0.00008460875,0.00362648,0.000003782759,0.00001324949,0.001148519,0.00001757869,0.001139017,0.9873332,0.0002057072,0.006406701,0.000004720064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97664,0.001705278,0.01295045,0.0002623445,0.0001062829,0.00003552981,0.001912962,0.0005226427,0.005864468],"genre_scores_gemma":[0.993469,0.0002970658,0.00183584,0.00004190639,0.00001190678,0.00001422025,0.001594952,0.0000589105,0.002676034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002927914,"threshold_uncertainty_score":0.009794772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02387949964659244,"score_gpt":0.258944653899506,"score_spread":0.2350651542529136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}