{"id":"W4220849859","doi":"10.1128/jvi.00128-22","title":"Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity","year":2022,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":191,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health; Agence Nationale de la Recherche; Government of Canada; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Furin; Infectivity; Biology; Virology; TMPRSS2; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Betacoronavirus; Coronavirus; Virus; Computational biology; Genetics; Outbreak","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002017724,0.00006594005,0.0001784506,0.00006944741,0.00002799737,0.000002573735,0.00008453948,0.00004286717,0.00001042195],"category_scores_gemma":[0.0001006224,0.00005950404,0.00006232277,0.00004364239,0.00007454788,0.000003086945,0.0001458769,0.0001405257,1.495487e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001141224,"about_ca_system_score_gemma":0.00005309449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001998595,"about_ca_topic_score_gemma":0.00006234081,"domain_scores_codex":[0.9993445,0.000151613,0.0002211017,0.0001023614,0.00007944573,0.0001009985],"domain_scores_gemma":[0.9996117,0.0000264249,0.0002140901,0.00008514174,0.00003361846,0.00002903265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000659733,0.0002433274,0.1257879,0.00001256595,0.00004118048,0.00005441465,0.00007932405,0.000267738,0.8712798,0.0001459713,0.0001912416,0.001236744],"study_design_scores_gemma":[0.004169555,0.004220834,0.4407716,0.00001515253,0.00007528794,0.00072266,0.0003929022,0.0002092469,0.5397208,0.002064277,0.007399682,0.0002379341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983692,0.0009606387,0.000121478,0.000134234,0.00007439868,0.00003977419,0.00001814062,7.071837e-7,0.0002813902],"genre_scores_gemma":[0.99964,0.0001280315,0.00004824581,0.0001211259,0.00004364865,0.000003984489,0.000003022517,0.000005286451,0.000006599673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.331559,"threshold_uncertainty_score":0.2426504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007108644495292855,"score_gpt":0.258798873086325,"score_spread":0.2516902285910322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}