{"id":"W4220849859","doi":"10.1128/jvi.00128-22","title":"Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity","year":2022,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":191,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health; Agence Nationale de la Recherche; Government of Canada; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Furin; Infectivity; Biology; Virology; TMPRSS2; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); 2019-20 coronavirus outbreak; Betacoronavirus; Coronavirus; Virus; Computational biology; Genetics; Outbreak","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001703499,0.0002369681,0.0002532947,0.0001904484,0.0001657362,0.0003796414,0.0001462313,0.0002623851,0.0005383185],"category_scores_gemma":[0.0001522612,0.0001398511,0.0002857249,0.00007564716,0.0002470204,0.0004249196,0.0002785614,0.0002722953,0.0001820667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002644584,"about_ca_system_score_gemma":0.0001848774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002932338,"about_ca_topic_score_gemma":0.0002559073,"domain_scores_codex":[0.9998788,0.00002529546,0.000007952762,0.0000165621,0.00002594723,0.00004545039],"domain_scores_gemma":[0.9999363,0.00001115558,0.00001530862,0.000007381358,0.000009725299,0.00002005688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001623763,0.00001497039,0.0005474545,0.00001886605,0.000002781721,0.00007472414,0.00002124044,0.00008240691,0.9980295,0.0002447102,0.00001852421,0.0007824207],"study_design_scores_gemma":[0.00003806003,0.000905883,0.08867723,0.00001587367,0.00002844303,0.002283487,0.0002442198,0.005411937,0.8983952,0.0007072269,0.003261773,0.00003062429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953657,0.002087252,0.001227375,0.0000628831,0.00001220633,0.000009432253,0.00008878261,0.00001750355,0.00112882],"genre_scores_gemma":[0.998362,0.0004019985,0.0004877895,0.00002275047,0.000008593437,0.00000802365,0.0001147784,0.000004875002,0.0005892852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005383185,"threshold_uncertainty_score":0.001918852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007108644495292855,"score_gpt":0.258798873086325,"score_spread":0.2516902285910322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}