{"id":"W4220850458","doi":"10.7554/elife.74623","title":"ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Universität für Bodenkultur Wien; Medizinische Universität Wien; Canada Research Chairs; Austrian Science Fund; Innovative Medicines Initiative; Universität Wien; Österreichischen Akademie der Wissenschaften","keywords":"Immunopathology; Immunology; Proinflammatory cytokine; Cytokine; Immune system; Biology; In vivo; Tumor necrosis factor alpha; Cytokine storm; Virology; Medicine; Coronavirus disease 2019 (COVID-19); Inflammation; Disease; Infectious disease (medical specialty); Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003898246,0.001292587,0.0004775936,0.0008141064,0.0003207973,0.0005852316,0.0004326707,0.0009622194,0.002268081],"category_scores_gemma":[0.0001407294,0.000384778,0.0006245432,0.0002776858,0.0006360169,0.0006146614,0.0003362659,0.002348764,0.0007662694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000500541,"about_ca_system_score_gemma":0.0003271143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005134088,"about_ca_topic_score_gemma":0.0009015507,"domain_scores_codex":[0.9995738,0.00006704768,0.00005228351,0.0001183299,0.0001006311,0.0000878927],"domain_scores_gemma":[0.9996777,0.00002627215,0.0001211494,0.00003801099,0.00002000648,0.0001168752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003563222,0.0001304436,0.0002486481,0.00003510628,0.000008153395,0.0001337101,0.00002210288,0.0001097726,0.997972,0.0003097127,0.00006054512,0.000613464],"study_design_scores_gemma":[0.0001306005,0.001775941,0.004143191,0.00002698218,0.00004205461,0.001363287,0.00009360669,0.002240506,0.9844594,0.0002664939,0.005443061,0.00001492868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835348,0.001300215,0.01009839,0.0004552847,0.0001398703,0.0001538547,0.001692393,0.0002325511,0.002392795],"genre_scores_gemma":[0.9742122,0.001239263,0.01078011,0.0001867374,0.00004182747,0.0002412026,0.002322588,0.0001180478,0.01085804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002268081,"threshold_uncertainty_score":0.007587492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07382100808579341,"score_gpt":0.3851850555959817,"score_spread":0.3113640475101883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}