{"id":"W4220851619","doi":"10.1161/circulationaha.121.057687","title":"Clinical Trial Design Principles and Outcomes Definitions for Device-Based Therapies for Hypertension: A Consensus Document From the Hypertension Academic Research Consortium","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Blood Pressure and Hypertension Studies","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Sunnybrook Health Science Centre","funders":"Idorsia Pharmaceuticals; Servier; Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.; Istituto Auxologico Italiano; Institut National de la Santé et de la Recherche Médicale; Universität des Saarlandes; University of Pennsylvania; Università degli Studi di Milano-Bicocca; Deutsche Forschungsgemeinschaft; Omron Healthcare; Queen Mary University of London; National Institute for Health and Care Research; ReCor Medical; Perelman School of Medicine, University of Pennsylvania; Medicines Company; Biosensors International Group; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Regeneron Pharmaceuticals; Boston Scientific Corporation; Massachusetts Institute of Technology; Alnylam Pharmaceuticals; Cytokinetics; Abbott Vascular; Brigham and Women's Hospital; University of Exeter; Amgen; Pfizer; Eli Lilly and Company; National Health and Medical Research Council; AstraZeneca","keywords":"Clinical trial; Alternative medicine; Consistency (knowledge bases); Clinical research; Research design; MEDLINE; Blood pressure; Clinical study design","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.003089433,0.0001675421,0.0006001355,0.0001007252,0.001438982,0.00003288857,0.00009196497,0.0001443493,0.0000285201],"category_scores_gemma":[0.002014974,0.0001120671,0.0002155287,0.0001516065,0.0002736936,0.00003412999,0.0001013241,0.0004600341,0.000003058927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003055937,"about_ca_system_score_gemma":0.0002680485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004663385,"about_ca_topic_score_gemma":0.000009726167,"domain_scores_codex":[0.9973803,0.0007074592,0.0006545715,0.0004703476,0.0004980766,0.0002892466],"domain_scores_gemma":[0.9839129,0.0148509,0.0001756208,0.0003705537,0.0005995407,0.00009051735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2285462,0.003435368,0.4468684,0.0004742828,0.007482081,0.0001420493,0.003977622,0.00200946,0.02615461,0.02008449,0.2056054,0.05522],"study_design_scores_gemma":[0.1442188,0.003224848,0.5945041,0.0002141472,0.004927577,0.0001266383,0.005015201,0.0229968,0.0003498947,0.02021598,0.2035757,0.0006303153],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9388172,0.01018831,0.002121296,0.04204962,0.0006404883,0.005947793,0.0001213427,0.00008502231,0.000028904],"genre_scores_gemma":[0.9849741,0.000206581,0.004855898,0.007911748,0.0003838174,0.001458849,0.000140624,0.00003123095,0.0000371308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1476357,"threshold_uncertainty_score":0.999861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5579763374903878,"score_gpt":0.4420138542317787,"score_spread":0.115962483258609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}