{"id":"W4220851619","doi":"10.1161/circulationaha.121.057687","title":"Clinical Trial Design Principles and Outcomes Definitions for Device-Based Therapies for Hypertension: A Consensus Document From the Hypertension Academic Research Consortium","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Blood Pressure and Hypertension Studies","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Sunnybrook Health Science Centre","funders":"Idorsia Pharmaceuticals; Servier; Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.; Istituto Auxologico Italiano; Institut National de la Santé et de la Recherche Médicale; Universität des Saarlandes; University of Pennsylvania; Università degli Studi di Milano-Bicocca; Deutsche Forschungsgemeinschaft; Omron Healthcare; Queen Mary University of London; National Institute for Health and Care Research; ReCor Medical; Perelman School of Medicine, University of Pennsylvania; Medicines Company; Biosensors International Group; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Regeneron Pharmaceuticals; Boston Scientific Corporation; Massachusetts Institute of Technology; Alnylam Pharmaceuticals; Cytokinetics; Abbott Vascular; Brigham and Women's Hospital; University of Exeter; Amgen; Pfizer; Eli Lilly and Company; National Health and Medical Research Council; AstraZeneca","keywords":"Clinical trial; Alternative medicine; Consistency (knowledge bases); Clinical research; Research design; MEDLINE; Blood pressure; Clinical study design","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.7053436,0.003854303,0.009923017,0.01107182,0.008194116,0.0261288,0.01490771,0.0378599,0.003021136],"category_scores_gemma":[0.6014884,0.005114367,0.01373914,0.009959444,0.01676918,0.00949457,0.01378207,0.05570336,0.005294574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01553834,"about_ca_system_score_gemma":0.1143293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005396653,"about_ca_topic_score_gemma":0.007939455,"domain_scores_codex":[0.2509247,0.4930928,0.1598955,0.01077519,0.07824636,0.007065531],"domain_scores_gemma":[0.2030454,0.4788622,0.05092647,0.04658193,0.2037337,0.01685023],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0012876,0.0006900093,0.002155694,0.01449368,0.0008853002,0.0007771486,0.00808568,0.003603538,0.002053675,0.2951969,0.4937851,0.1769856],"study_design_scores_gemma":[0.00369442,0.001263863,0.003250178,0.04227076,0.001429,0.001122749,0.001952923,0.004455029,0.003107852,0.1446992,0.7921026,0.0006513815],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.002475885,0.03080905,0.4100706,0.4277184,0.02907372,0.06273922,0.004446918,0.001451949,0.03121435],"genre_scores_gemma":[0.01072687,0.01011686,0.779859,0.1051223,0.006109796,0.07901755,0.002684503,0.0004632963,0.005899813],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.2946564,"threshold_uncertainty_score":0.3633639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5579763374903878,"score_gpt":0.4420138542317787,"score_spread":0.115962483258609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}