{"id":"W4220854540","doi":"10.1158/2767-9764.crc-21-0119","title":"A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women","year":2022,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Queen's University; Centre hospitalier universitaire de Québec; Canadian Centre for Applied Research in Cancer Control","funders":"National Institute of Environmental Health Sciences; Cancer Research UK; National Institutes of Health; National Cancer Institute; Medical Research Council; National Health and Medical Research Council","keywords":"Genome-wide association study; Breast cancer; Bonferroni correction; Heritability; Biology; Genetic association; Gene–environment interaction; Genetics; Gene; Genotype; Transcriptome; Missing heritability problem; Expression quantitative trait loci; Gene interaction; Population; Cancer; Gene expression; Oncology; Single-nucleotide polymorphism; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009910058,0.0002346158,0.0003768117,0.0004074284,0.000709619,0.0004212475,0.0002524668,0.0003526754,0.001138761],"category_scores_gemma":[0.00202035,0.0002967004,0.0004478748,0.001210304,0.0002988201,0.0002178576,0.0005274993,0.0005946386,0.0001870417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002447018,"about_ca_system_score_gemma":0.0003505206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005945475,"about_ca_topic_score_gemma":0.010036,"domain_scores_codex":[0.9991826,0.0003384468,0.00004338676,0.0002651649,0.0001034773,0.00006690521],"domain_scores_gemma":[0.9991809,0.0003039117,0.0001817258,0.0001618556,0.00006717694,0.0001043818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001955558,0.0000544748,0.9946202,0.00002118533,0.00039182,0.0001449358,0.0002210467,0.00009850021,0.002058634,0.00003967202,0.0002059284,0.001948117],"study_design_scores_gemma":[0.00001238468,0.00006930946,0.9987562,0.000003327174,0.0001612302,0.0001805911,0.0001013942,0.0001095689,0.00009958912,0.0000528701,0.0004502594,0.000003239072],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980258,0.0002140761,0.0003778587,0.00008654573,0.000004766401,0.0000110742,0.001005776,0.000007103997,0.0002669729],"genre_scores_gemma":[0.9982952,0.000107284,0.0004450354,0.00006841821,0.000007444258,0.00002228636,0.0008498242,0.000006039916,0.0001983407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005945475,"threshold_uncertainty_score":0.01182175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0649796946101617,"score_gpt":0.3962778853050389,"score_spread":0.3312981906948772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}