{"id":"W4220858928","doi":"10.1101/2022.03.31.486523","title":"WWP2 osteoarthritis risk allele rs1052429-A confers risk by affecting cartilage matrix deposition via hypoxia associated genes","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"ZonMw; Universiteit Leiden; Leids Universitair Medisch Centrum; European Commission; Arthritis Society; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Dutch Arthritis Society","keywords":"Downregulation and upregulation; Cartilage; Chondrocyte; Osteoarthritis; Biology; SOX9; Gene; Gene expression; Chondrogenesis; Internal medicine; Cell biology; Endocrinology; Anatomy; Genetics; Pathology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269581,0.0003667925,0.0002976493,0.0004981708,0.000152745,0.0002520093,0.0001057817,0.0002686278,0.003059034],"category_scores_gemma":[0.0002276829,0.0001373102,0.0003598316,0.0003356377,0.0001442142,0.00007107713,0.0001814193,0.0002348262,0.0003120935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008203666,"about_ca_system_score_gemma":0.00009026533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006883207,"about_ca_topic_score_gemma":0.001147334,"domain_scores_codex":[0.9997754,0.00004106698,0.00002171065,0.00008475051,0.00005210751,0.00002507826],"domain_scores_gemma":[0.9997731,0.0000346723,0.0001208105,0.00001870775,0.00001351727,0.00003918573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001366395,0.00004227767,0.04984848,0.0000902779,0.0002069201,0.0008579079,0.00004811241,0.0002900794,0.9441026,0.0001368217,0.0002536406,0.002756342],"study_design_scores_gemma":[0.00006660911,0.000519146,0.8743622,0.00002506838,0.0002650089,0.005056194,0.0001293227,0.003472765,0.113075,0.0002701672,0.002734944,0.00002353868],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968833,0.0003685875,0.00145012,0.00003661656,0.00001463857,0.000007080372,0.0007610754,0.00003572631,0.0004428251],"genre_scores_gemma":[0.998015,0.00009549526,0.0006346891,0.00002913702,0.000009715958,0.00001528405,0.0004383038,0.00001374655,0.0007485162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003059034,"threshold_uncertainty_score":0.01023346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007436402305511554,"score_gpt":0.2189147700642727,"score_spread":0.2114783677587612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}