{"id":"W4220860149","doi":"10.15252/emmm.202114297","title":"Autologous, lentivirus‐modified, T‐rapa cell “micropharmacies” for lysosomal storage disorders","year":2022,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Hospital; Western University; McMaster University; University of Toronto","funders":"Midwest Athletes Against Childhood Cancer; Hope Foundation","keywords":"Ex vivo; Lentivirus; In vivo; Immunology; Biology; Cancer research; Medicine; Pharmacology; Biotechnology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416058,0.0002825228,0.0001610223,0.0002359391,0.0001605849,0.0003424579,0.0001736542,0.0003547176,0.001581549],"category_scores_gemma":[0.0000866847,0.0000859517,0.000183166,0.0001027333,0.0001883452,0.0002079461,0.0001374437,0.0005816075,0.0004963382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002230235,"about_ca_system_score_gemma":0.0001621611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003132265,"about_ca_topic_score_gemma":0.00029466,"domain_scores_codex":[0.9998969,0.0000199126,0.00001153711,0.00002190361,0.00003038777,0.00001937815],"domain_scores_gemma":[0.9999419,0.00001147156,0.00001917248,0.000009827886,0.000005962631,0.00001160908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009277651,0.00007928017,0.0001368165,0.00004152076,0.000006925719,0.00007550183,0.00001624671,0.0002878492,0.9950157,0.0003647245,0.0001726902,0.003710089],"study_design_scores_gemma":[0.00001356466,0.0003264708,0.0004335616,0.000003452138,0.00001518609,0.0002913444,0.000005427123,0.001080335,0.9946986,0.00004002429,0.003088933,0.0000030845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738133,0.002738767,0.01852929,0.0001826258,0.0001110976,0.0001499708,0.0005203665,0.000341782,0.003612836],"genre_scores_gemma":[0.9885485,0.0007016924,0.007608203,0.00004983815,0.00001867473,0.00007034736,0.000317619,0.00002541239,0.002659722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001581549,"threshold_uncertainty_score":0.005290806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02256614108770178,"score_gpt":0.3137677057689892,"score_spread":0.2912015646812874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}