{"id":"W4220860149","doi":"10.15252/emmm.202114297","title":"Autologous, lentivirus‐modified, T‐rapa cell “micropharmacies” for lysosomal storage disorders","year":2022,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Hospital; Western University; McMaster University; University of Toronto","funders":"Midwest Athletes Against Childhood Cancer; Hope Foundation","keywords":"Ex vivo; Lentivirus; In vivo; Immunology; Biology; Cancer research; Medicine; Pharmacology; Biotechnology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008510918,0.00036386,0.0006830663,0.0004350095,0.0003912749,0.00001607493,0.0004140263,0.00009549866,0.008092714],"category_scores_gemma":[0.0001569609,0.0003378879,0.0003211126,0.0006484903,0.0003526654,0.00005092126,0.0002597198,0.0007782423,0.00003002177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003074685,"about_ca_system_score_gemma":0.0002548603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001028486,"about_ca_topic_score_gemma":0.000004656991,"domain_scores_codex":[0.9967446,0.0002661743,0.0004714246,0.0007081084,0.001002829,0.0008068664],"domain_scores_gemma":[0.9984242,0.0001718697,0.0001825499,0.0007486335,0.0001349821,0.0003377111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001454138,0.000452049,0.0001981389,0.0002646111,0.0002105553,0.0005000588,0.0007831585,0.0002247404,0.9623973,0.0005659916,0.02247237,0.01047694],"study_design_scores_gemma":[0.02096844,0.004319737,0.0004729676,0.00006036453,0.000494584,0.0003370704,0.001259504,0.003935814,0.1078967,0.001291921,0.8583215,0.0006413339],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.866308,0.0114757,0.01986676,0.02337193,0.001599389,0.005027639,0.0001093548,0.00041419,0.07182707],"genre_scores_gemma":[0.9725277,0.0002042806,0.0003872406,0.004883124,0.0003688575,0.0005769201,0.0002983869,0.0001515874,0.02060184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8545005,"threshold_uncertainty_score":0.9999073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02256614108770178,"score_gpt":0.3137677057689892,"score_spread":0.2912015646812874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}