{"id":"W4220862841","doi":"10.1002/hep.32461","title":"Polo‐like kinase 4 inhibitor CFI‐400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity","year":2022,"lang":"en","type":"article","venue":"Hepatology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Health and Medical Research Fund; University of Hong Kong; Croucher Foundation","keywords":"Biology; Centrosome; Cancer research; DNA damage; Cell biology; Phenocopy; Cell cycle; Immune system; DNA repair; Immunology; Apoptosis; Phenotype; Gene; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006747099,0.000331104,0.0001940664,0.0002662978,0.0001070592,0.0001084936,0.0001402377,0.000170544,0.001320151],"category_scores_gemma":[0.00004814395,0.00007230334,0.0001536295,0.0001137156,0.0001576191,0.0001106276,0.00008271063,0.0003773283,0.0001834789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002389499,"about_ca_system_score_gemma":0.0002187996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002894441,"about_ca_topic_score_gemma":0.0005259354,"domain_scores_codex":[0.9999607,0.000004950425,0.000003879738,0.000006201005,0.000009463765,0.00001487064],"domain_scores_gemma":[0.9999684,0.000004752123,0.000008980987,0.000003682319,0.000003360094,0.000010847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007238021,0.0002290784,0.0004314862,0.0001033136,0.00001152837,0.00007341139,0.000009446786,0.0002751441,0.9893358,0.0001269343,0.0001867593,0.00849334],"study_design_scores_gemma":[0.0001763896,0.002495049,0.004180021,0.000007879522,0.00002835731,0.000320748,0.00001361492,0.001240995,0.9887432,0.00005340877,0.002735841,0.00000441849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952375,0.001874651,0.0008016049,0.0001230791,0.00003657351,0.00004136203,0.0002107737,0.0001443819,0.001530075],"genre_scores_gemma":[0.996686,0.0008481551,0.0006410614,0.00004808258,0.00001173444,0.00003593688,0.0002793566,0.000006624834,0.001442954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320151,"threshold_uncertainty_score":0.004416347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00897784238553929,"score_gpt":0.237387088036563,"score_spread":0.2284092456510237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}