{"id":"W4220862841","doi":"10.1002/hep.32461","title":"Polo‐like kinase 4 inhibitor CFI‐400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity","year":2022,"lang":"en","type":"article","venue":"Hepatology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Health and Medical Research Fund; University of Hong Kong; Croucher Foundation","keywords":"Biology; Centrosome; Cancer research; DNA damage; Cell biology; Phenocopy; Cell cycle; Immune system; DNA repair; Immunology; Apoptosis; Phenotype; Gene; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008611603,0.000154221,0.000174646,0.00003569913,0.0003440059,0.00001635142,0.0001511563,0.0001131063,0.0001661233],"category_scores_gemma":[0.00002381851,0.0001661339,0.00005137999,0.00007876557,0.0001020644,0.000008232133,0.0003785833,0.0001874197,0.000003760156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002856401,"about_ca_system_score_gemma":0.00008998849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002477,"about_ca_topic_score_gemma":0.0002425582,"domain_scores_codex":[0.9989528,0.0001633774,0.0001838648,0.0003433429,0.00007790598,0.0002787044],"domain_scores_gemma":[0.9995251,0.00002252408,0.0000990823,0.0002546174,0.00005398911,0.00004469134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001101195,0.0001602464,0.02904832,0.00007328275,0.00003700564,0.0000285465,0.0004239895,0.0000692313,0.9620044,0.0001775235,0.007039285,0.0008280345],"study_design_scores_gemma":[0.001585887,0.0006053033,0.002983676,0.00001594959,0.0000938742,0.0002866403,0.0009902122,0.003562521,0.7371504,0.0002986565,0.2517448,0.0006821405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922263,0.006328236,0.0001934017,0.0002520263,0.0002968645,0.0001647823,0.0001191632,0.00001894958,0.0004002526],"genre_scores_gemma":[0.9949304,0.00226192,0.0002740161,0.001580245,0.000141146,0.00008061485,0.0003007067,0.00002500014,0.0004059354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2447055,"threshold_uncertainty_score":0.6774743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00897784238553929,"score_gpt":0.237387088036563,"score_spread":0.2284092456510237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}