{"id":"W4220864844","doi":"10.1038/s41586-022-04650-z","title":"Age-dependent formation of TMEM106B amyloid filaments in human brains","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"NIHR Cambridge Biomedical Research Centre; Japan Society for the Promotion of Science; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology,University College London; National Center of Neurology and Psychiatry; National Institutes of Health; National Institute on Aging; Rossy Foundation; School of Medicine, Indiana University; Biotechnology and Biological Sciences Research Council; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Diamond Light Source; Wellcome Trust; Japan Agency for Medical Research and Development","keywords":"Amyloid (mycology); Chemistry; Cytoplasmic inclusion; Neurofilament; Cytoplasm; Biology; Biochemistry; Immunohistochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736955,0.0002564383,0.0001530929,0.0006123999,0.0002529769,0.0002370279,0.0001018234,0.0004198702,0.001319232],"category_scores_gemma":[0.0003071027,0.0002186599,0.0001780384,0.0001907533,0.0001567789,0.0001621099,0.0001998436,0.0002974569,0.000571044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001155913,"about_ca_system_score_gemma":0.00004910834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004903182,"about_ca_topic_score_gemma":0.0003147346,"domain_scores_codex":[0.9999115,0.00001282731,0.000009396555,0.00002711127,0.00002500868,0.00001405892],"domain_scores_gemma":[0.9998028,0.00001901867,0.00008011482,0.00001917806,0.0000425986,0.0000363761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005572616,0.00004966923,0.02250126,0.00005042875,0.00003999241,0.001738387,0.0002032292,0.00006137632,0.9717561,0.00005321204,0.0002265472,0.00276247],"study_design_scores_gemma":[0.00004255884,0.0007664519,0.8355759,0.00002653845,0.0000644047,0.02587022,0.00016987,0.0006040722,0.133533,0.0002442838,0.003088089,0.00001469129],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975514,0.0008910413,0.0005369761,0.00002714737,0.000009000266,0.00001492275,0.0002416909,0.00002901722,0.0006987397],"genre_scores_gemma":[0.9970898,0.0005047939,0.0007720582,0.00004778343,0.000009626993,0.00002160773,0.000792564,0.00001302104,0.0007487835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001319232,"threshold_uncertainty_score":0.004413247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02036042871416291,"score_gpt":0.3348838833478546,"score_spread":0.3145234546336917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}