{"id":"W4220865063","doi":"10.1126/sciadv.abm2536","title":"Structural basis for HCMV Pentamer receptor recognition and antibody neutralization","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Microsemi (Canada)","funders":"Genentech; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Pentamer; Antibody; Neutralization; Human cytomegalovirus; Virology; Neutralizing antibody; Immunology; Receptor; Biology; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006526081,0.0002316623,0.000170698,0.00007635741,0.0002339227,0.0002128392,0.0002472815,0.0003172017,0.001412062],"category_scores_gemma":[0.0001450371,0.0001489444,0.0001915549,0.00004683585,0.0001796703,0.0001951018,0.0002471301,0.0005143231,0.0003517671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002765972,"about_ca_system_score_gemma":0.0001932134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004911295,"about_ca_topic_score_gemma":0.0005584655,"domain_scores_codex":[0.9999058,0.0000182444,0.00000437757,0.00002288976,0.00002469642,0.00002396485],"domain_scores_gemma":[0.999953,0.000007667617,0.00001168222,0.000005350491,0.000006039454,0.00001619488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001114458,0.00003948882,0.0005361608,0.00003661916,0.000009959649,0.0002771094,0.00004013651,0.0007604436,0.9952707,0.001278513,0.0001882161,0.001451226],"study_design_scores_gemma":[0.0001140939,0.0007624016,0.01604102,0.00002261467,0.00003166045,0.00258701,0.0001953318,0.02287251,0.9434236,0.002519657,0.01140615,0.00002396059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833295,0.001322071,0.0100587,0.0002440802,0.0000468043,0.00004969702,0.0001192496,0.00006826202,0.004761698],"genre_scores_gemma":[0.9955814,0.0002450516,0.002802921,0.0001363496,0.000008134477,0.00001251447,0.0002031218,0.000007211017,0.001003166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001412062,"threshold_uncertainty_score":0.004723847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05181839731764605,"score_gpt":0.3783969795284024,"score_spread":0.3265785822107564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}