{"id":"W4220865063","doi":"10.1126/sciadv.abm2536","title":"Structural basis for HCMV Pentamer receptor recognition and antibody neutralization","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Microsemi (Canada)","funders":"Genentech; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Pentamer; Antibody; Neutralization; Human cytomegalovirus; Virology; Neutralizing antibody; Immunology; Receptor; Biology; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003886704,0.00006145792,0.0001019468,0.0001667327,0.0006912096,0.00004824025,0.00009322789,0.00001073486,0.0007368534],"category_scores_gemma":[0.0001170718,0.00005253888,0.00002636825,0.0005737302,0.0002958944,0.000511001,0.0000668896,0.00008649411,0.000008952075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008074322,"about_ca_system_score_gemma":0.0001250046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003800053,"about_ca_topic_score_gemma":0.00001051629,"domain_scores_codex":[0.9989603,0.00001795491,0.0001087089,0.0002806192,0.0003972815,0.0002352004],"domain_scores_gemma":[0.9996112,0.0000442592,0.00004255564,0.00009325937,0.000115972,0.00009276044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000468709,0.00004975874,0.02085824,0.0001012193,0.00000828362,0.000002686266,0.0006379865,0.00004637352,0.5822062,0.0002465677,0.0004081204,0.3949659],"study_design_scores_gemma":[0.004869296,0.004045465,0.1206284,0.0001534368,0.0001075561,0.0001953969,0.008747428,0.005847148,0.3031033,0.006118935,0.5452615,0.0009221629],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974014,0.0006475539,0.0001133732,0.0007054529,0.0002404331,0.0004268246,0.00008667378,0.00002363071,0.0003546296],"genre_scores_gemma":[0.9970695,0.0002085188,0.001797886,0.0003167496,0.00008383516,0.00007145039,0.00008433379,0.000007905438,0.0003598096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5448534,"threshold_uncertainty_score":0.8068028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05181839731764605,"score_gpt":0.3783969795284024,"score_spread":0.3265785822107564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}