{"id":"W4220870634","doi":"10.1158/1538-7445.sabcs21-ot2-11-06","title":"Abstract OT2-11-06: SERENA-4: A Phase III comparison of AZD9833 (camizestrant) plus palbociclib, versus anastrozole plus palbociclib, for patients with ER-positive/HER2-negative advanced breast cancer who have not previously received systemic treatment for advanced disease","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Palbociclib; Medicine; Fulvestrant; Breast cancer; Internal medicine; Anastrozole; Cancer; Oncology; Letrozole; Aromatase inhibitor; Estrogen receptor; Tamoxifen; Pharmacology; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009917615,0.001662132,0.001510807,0.0004894385,0.0003092121,0.001199122,0.001094795,0.00127555,0.007559498],"category_scores_gemma":[0.0005874506,0.0005729905,0.001436447,0.0004504764,0.0008026639,0.0007849438,0.0002630444,0.003882765,0.001595187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008173625,"about_ca_system_score_gemma":0.001217199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001614247,"about_ca_topic_score_gemma":0.004087716,"domain_scores_codex":[0.9998052,0.0000841339,0.00001046113,0.0000333142,0.00002362484,0.00004339082],"domain_scores_gemma":[0.9997076,0.00004594273,0.00005228188,0.00002373558,0.00002241417,0.0001479763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7526436,0.05995446,0.001874393,0.001619868,0.001621269,0.0001952015,0.0001821237,0.003180573,0.07005628,0.0006512369,0.00772235,0.1002985],"study_design_scores_gemma":[0.6141635,0.3669429,0.005921565,0.00008237693,0.0006987637,0.0002542247,0.00008743884,0.001875652,0.005764095,0.0002075947,0.003961944,0.00004003112],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800767,0.006139269,0.0007986372,0.0007568639,0.0004262889,0.003091103,0.002724711,0.0003461648,0.005640225],"genre_scores_gemma":[0.9736546,0.005871051,0.001810135,0.001004758,0.0002371032,0.002127822,0.005322258,0.00006358104,0.009908613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007559498,"threshold_uncertainty_score":0.02528906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06213605372637444,"score_gpt":0.4199130195451048,"score_spread":0.3577769658187304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}