{"id":"W4220870634","doi":"10.1158/1538-7445.sabcs21-ot2-11-06","title":"Abstract OT2-11-06: SERENA-4: A Phase III comparison of AZD9833 (camizestrant) plus palbociclib, versus anastrozole plus palbociclib, for patients with ER-positive/HER2-negative advanced breast cancer who have not previously received systemic treatment for advanced disease","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Palbociclib; Medicine; Fulvestrant; Breast cancer; Internal medicine; Anastrozole; Cancer; Oncology; Letrozole; Aromatase inhibitor; Estrogen receptor; Tamoxifen; Pharmacology; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005140124,0.0008583432,0.002002244,0.000428088,0.000973881,0.00006027488,0.0005947318,0.0001444801,0.000341806],"category_scores_gemma":[0.0001821151,0.0007466068,0.0004596192,0.0007654745,0.0006740929,0.0004534125,0.0001758693,0.0007439769,0.000003093887],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008041063,"about_ca_system_score_gemma":0.003685063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002629724,"about_ca_topic_score_gemma":0.00195387,"domain_scores_codex":[0.9932403,0.0003426325,0.001174832,0.001594576,0.001841838,0.001805825],"domain_scores_gemma":[0.9934208,0.001612013,0.0008881116,0.001024048,0.002179649,0.0008753582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7600138,0.004501785,0.01833022,0.00326464,0.002790119,0.00007134888,0.01085543,0.04936475,0.0125114,0.00007677409,0.0008147333,0.1374051],"study_design_scores_gemma":[0.7683812,0.03647248,0.07767586,0.01066067,0.002696904,0.00003651586,0.0307045,0.0111967,0.04532659,0.0001318387,0.01349767,0.003219094],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625297,0.00262623,0.0006509285,0.00151707,0.000367329,0.01463549,0.01749407,0.000130208,0.00004897345],"genre_scores_gemma":[0.9707326,0.0004830959,0.0009196447,0.0001028712,0.0003127684,0.02490474,0.001227699,0.0002757504,0.001040873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.134186,"threshold_uncertainty_score":0.9994985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06213605372637444,"score_gpt":0.4199130195451048,"score_spread":0.3577769658187304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}