{"id":"W4220872555","doi":"10.3390/brainsci12040434","title":"The Human Myelin Proteome and Sub-Metalloproteome Interaction Map: Relevance to Myelin-Related Neurological Diseases","year":2022,"lang":"en","type":"article","venue":"Brain Sciences","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Victoria University; Eli Lilly and Company","keywords":"Myelin; Proteome; In silico; Multiple sclerosis; Myelin basic protein; Proteomics; Biology; Citrullination; Computational biology; Human proteome project; Cell biology; Neuroscience; Immunology; Biochemistry; Gene; Central nervous system; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001941796,0.0003923467,0.000282362,0.001940199,0.0003201682,0.0004463141,0.0002162032,0.000261198,0.002319254],"category_scores_gemma":[0.000924975,0.00008924213,0.0004308389,0.003053273,0.0001151758,0.0004367472,0.0008328322,0.0002552535,0.0007307296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003328244,"about_ca_system_score_gemma":0.000416031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002441495,"about_ca_topic_score_gemma":0.002913709,"domain_scores_codex":[0.9998015,0.00003320326,0.00001473986,0.00008218684,0.0000427424,0.00002566106],"domain_scores_gemma":[0.999775,0.00006100483,0.00007086139,0.00002524863,0.00003275602,0.00003507826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004429925,0.000411483,0.406206,0.006452004,0.001949852,0.004621557,0.001239289,0.04822119,0.219981,0.01318023,0.06090803,0.2323994],"study_design_scores_gemma":[0.00007932126,0.0002284597,0.7626165,0.0002893206,0.0007675168,0.00499035,0.0007173132,0.07886481,0.02865662,0.02046171,0.1022454,0.00008261899],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7201105,0.00497573,0.01715016,0.0006958584,0.00003143836,0.00008502656,0.249893,0.0008840871,0.00617414],"genre_scores_gemma":[0.7742893,0.003361613,0.01980161,0.0001015426,0.00003171325,0.0001548728,0.200869,0.00008799437,0.001302234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002441495,"threshold_uncertainty_score":0.007758677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082424241952139,"score_gpt":0.2585013952573247,"score_spread":0.2476771528378033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}