{"id":"W4220872739","doi":"10.1158/1538-7445.sabcs21-ot1-11-02","title":"Abstract OT1-11-02: A pragmatic, randomised, multicentre trial evaluating the dose timing (morning vs evening) of endocrine therapy and its effects on tolerability and compliance (REaCT-CHRONO Study)","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; McMaster University; Thunder Bay Regional Health Sciences Centre; University of Ottawa","funders":"","keywords":"Tolerability; Medicine; Evening; Clinical endpoint; Breast cancer; Morning; Internal medicine; Cancer; Clinical trial; Oncology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004205374,0.001871592,0.003319273,0.0003837087,0.0005084014,0.001244815,0.001096317,0.002200611,0.01342379],"category_scores_gemma":[0.005128277,0.0006463511,0.002400395,0.0005290394,0.001608937,0.001332061,0.0007690225,0.003229755,0.001156218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007939511,"about_ca_system_score_gemma":0.001636106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009855269,"about_ca_topic_score_gemma":0.001865569,"domain_scores_codex":[0.997587,0.001747026,0.0001295555,0.0002483238,0.0001149862,0.0001731633],"domain_scores_gemma":[0.9969333,0.001042168,0.0008068376,0.0002122266,0.0001556464,0.0008497643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9811508,0.006583893,0.0002583794,0.001157679,0.0005457716,0.00003299243,0.0000487896,0.0001972738,0.001195368,0.0001568971,0.0007658349,0.00790628],"study_design_scores_gemma":[0.9443179,0.0540542,0.0006234884,0.00004963464,0.0002704129,0.00001765467,0.00002044066,0.0001216568,0.00008029101,0.00009852707,0.0003354085,0.00001044703],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695616,0.006048789,0.001379351,0.001895349,0.001374828,0.01320827,0.002389026,0.0001974031,0.003945359],"genre_scores_gemma":[0.9677283,0.002028356,0.004913125,0.002514195,0.001014733,0.01543852,0.001719518,0.00004863922,0.004594515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01342379,"threshold_uncertainty_score":0.04490709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2686467496825231,"score_gpt":0.5216192358242293,"score_spread":0.2529724861417062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}