{"id":"W4220873466","doi":"10.21203/rs.3.rs-1363426/v1","title":"Mid-pregnancy poly(I:C) viral mimic disrupts placental ABC transporter expression and leads to long-term offspring motor and cognitive dysfunction","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Pregnancy and Medication Impact","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Universidade Federal do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Bill and Melinda Gates Foundation","keywords":"Offspring; ABCG1; Pregnancy; Transplacental; Endocrinology; Fetus; Placenta; Andrology; Biology; Internal medicine; Transporter; ABCA1; Medicine; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001377472,0.000428481,0.0003321945,0.0003283694,0.0001573206,0.0003467711,0.0002791484,0.0003946307,0.001685558],"category_scores_gemma":[0.000134587,0.0002364224,0.0003407901,0.0001393589,0.0003317995,0.0002109999,0.000241282,0.001197375,0.0004463741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004753585,"about_ca_system_score_gemma":0.0002555265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009753133,"about_ca_topic_score_gemma":0.001224092,"domain_scores_codex":[0.9997793,0.00002456479,0.00002383591,0.00006973714,0.00004690001,0.00005562932],"domain_scores_gemma":[0.9997678,0.00003043332,0.0001034484,0.00002232256,0.00001427806,0.00006161182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003437223,0.00007622457,0.0002665192,0.00003321372,0.000006978526,0.0001317199,0.00002382243,0.00004109781,0.997733,0.00007447439,0.0000583711,0.001210811],"study_design_scores_gemma":[0.00004174321,0.002383081,0.01349624,0.0000312262,0.00004654101,0.0008627658,0.000133312,0.00128159,0.9790055,0.0001301447,0.002574172,0.00001369626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991843,0.002170796,0.002888355,0.0001871919,0.00008463229,0.00004584216,0.001115942,0.0001943305,0.001469763],"genre_scores_gemma":[0.9883875,0.001908636,0.002001685,0.0001540349,0.00001424431,0.00013035,0.001110404,0.00004914037,0.00624395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001685558,"threshold_uncertainty_score":0.005638778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05080354863726817,"score_gpt":0.3942225777880742,"score_spread":0.3434190291508061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}