{"id":"W4220874374","doi":"10.1002/cpz1.389","title":"Generation of Complex Syngeneic Liver Organoids from Induced Pluripotent Stem Cells to Model Human Liver Pathophysiology","year":2022,"lang":"en","type":"article","venue":"Current Protocols","topic":"Liver physiology and pathology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Induced pluripotent stem cell; Progenitor cell; Organoid; Biology; Mesenchymal stem cell; Cell biology; Stem cell; Endothelial stem cell; Directed differentiation; Cellular differentiation; Adult stem cell; Immunology; Embryonic stem cell; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00100485,0.0006049229,0.0003566901,0.000721262,0.0003307333,0.0004949964,0.0004889824,0.0005208314,0.004205048],"category_scores_gemma":[0.000440087,0.0003717218,0.000571484,0.0004305604,0.0004489753,0.0004865349,0.0005556835,0.001129383,0.002105052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003461117,"about_ca_system_score_gemma":0.0005951631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003733711,"about_ca_topic_score_gemma":0.0009641048,"domain_scores_codex":[0.9995498,0.00008616968,0.00007873768,0.00008209127,0.0001679228,0.00003525459],"domain_scores_gemma":[0.9995504,0.0001118528,0.0000780503,0.0001338,0.00007859143,0.00004719839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001032783,0.00006244437,0.0003951931,0.0002823007,0.00001966733,0.0002782492,0.000114581,0.001480238,0.986598,0.002579628,0.001050872,0.007035589],"study_design_scores_gemma":[0.00003130695,0.0002642463,0.001069446,0.00006577272,0.0000449696,0.0004166954,0.00005695445,0.001858313,0.956661,0.0005517181,0.03896171,0.00001790354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3375555,0.005172891,0.5948025,0.0007891782,0.000803639,0.007603519,0.02192791,0.002525397,0.02881955],"genre_scores_gemma":[0.5574585,0.006655463,0.3849474,0.0005747502,0.00006647711,0.009156126,0.02161328,0.0005674759,0.01896046],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.004205048,"threshold_uncertainty_score":0.01406729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2682015068038122,"score_gpt":0.373615545731011,"score_spread":0.1054140389271987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}