{"id":"W4220877871","doi":"10.2174/1573406418666220322154110","title":"1-[4-(2-Dimethylaminoethoxy)phenylcarbonyl]-3,5-Bis(3,4,5-Trimethoxybenzylidene)-4-Piperidone Hydrochloride and Related Compounds: PotentCytotoxins Demonstrate Greater Toxicity to Neoplasms than Non-Malignant Cells","year":2022,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Mitacs","keywords":"Cytotoxicity; Toxicity; Chemistry; Potency; Apoptosis; Pharmacology; Doxorubicin; Chemotherapy; Stereochemistry; Cancer research; Toxicology; In vitro; Medicine; Biology; Biochemistry; Internal medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001330591,0.0002844271,0.0001954496,0.0001217838,0.00008087388,0.0001002374,0.0001591603,0.0001641543,0.001409242],"category_scores_gemma":[0.0001241283,0.00009019313,0.0001692582,0.0001338126,0.0001374444,0.0001577708,0.0001119637,0.0003737488,0.0004185945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000115672,"about_ca_system_score_gemma":0.0001807513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002816345,"about_ca_topic_score_gemma":0.0006803611,"domain_scores_codex":[0.9999076,0.0000217326,0.000007990144,0.00001727803,0.00003050392,0.00001485391],"domain_scores_gemma":[0.9999107,0.00001857157,0.00004366878,0.000007930257,0.00001023622,0.000008917792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001637926,0.00009881713,0.0003330762,0.0002359937,0.0000106513,0.00006823941,0.00001078693,0.0007706466,0.9899637,0.0001590921,0.00009241283,0.008092819],"study_design_scores_gemma":[0.0000891517,0.004695004,0.006649379,0.00003185782,0.00004147676,0.0005836572,0.00002155807,0.002524042,0.9772221,0.0000806843,0.008046316,0.0000147371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725918,0.0128019,0.009110854,0.000177743,0.00005500957,0.00008655261,0.0003892496,0.0001002818,0.00468676],"genre_scores_gemma":[0.9855752,0.005413717,0.006015,0.00007088952,0.00002055101,0.00005364328,0.0004209925,0.000009092908,0.002420917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409242,"threshold_uncertainty_score":0.00471437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148454478787289,"score_gpt":0.2159848677169511,"score_spread":0.2045003229290782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}