{"id":"W4220877871","doi":"10.2174/1573406418666220322154110","title":"1-[4-(2-Dimethylaminoethoxy)phenylcarbonyl]-3,5-Bis(3,4,5-Trimethoxybenzylidene)-4-Piperidone Hydrochloride and Related Compounds: PotentCytotoxins Demonstrate Greater Toxicity to Neoplasms than Non-Malignant Cells","year":2022,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Mitacs","keywords":"Cytotoxicity; Toxicity; Chemistry; Potency; Apoptosis; Pharmacology; Doxorubicin; Chemotherapy; Stereochemistry; Cancer research; Toxicology; In vitro; Medicine; Biology; Biochemistry; Internal medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001053463,0.0007228955,0.001016277,0.00008392815,0.0006397083,0.00008066676,0.0007404351,0.0003960085,0.003069403],"category_scores_gemma":[0.0002607964,0.0006102666,0.000290798,0.0004588248,0.0003546078,0.0001003573,0.0008279008,0.00124944,0.00002294201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003542275,"about_ca_system_score_gemma":0.0001555763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003240258,"about_ca_topic_score_gemma":0.000007028561,"domain_scores_codex":[0.995682,0.0001425597,0.0008675646,0.001379592,0.0009279003,0.001000368],"domain_scores_gemma":[0.997506,0.0005232914,0.0003713964,0.0007813147,0.0000815305,0.0007364167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004394607,0.0003054522,0.003855634,0.0001809311,0.0001436715,0.0003927539,0.0002898553,0.00002987281,0.990649,0.000003558713,0.0002851001,0.003424648],"study_design_scores_gemma":[0.001050505,0.000189602,0.002252724,0.0001257914,0.0001487574,0.0006192846,0.001231041,0.0003705718,0.9910119,0.0001605003,0.002043211,0.0007961153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769685,0.0003953622,0.00006411856,0.0005300947,0.0002803396,0.0002358007,0.0001763409,0.0002156125,0.02113381],"genre_scores_gemma":[0.9951366,0.00005762988,0.0005352665,0.0003276406,0.0003600662,0.0001594764,0.00006990117,0.00006816451,0.003285215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01816812,"threshold_uncertainty_score":0.9996349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148454478787289,"score_gpt":0.2159848677169511,"score_spread":0.2045003229290782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}