{"id":"W4220879423","doi":"10.1016/j.jtho.2022.02.011","title":"Concurrent TP53 Mutations Facilitate Resistance Evolution in EGFR-Mutant Lung Adenocarcinoma","year":2022,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":154,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Loxo Oncology; Sanofi Genzyme; Takeda Oncology; EMD Serono; Genentech; National Institutes of Health; Astellas Pharma; Daiichi-Sankyo; Damon Runyon Cancer Research Foundation; Revolution Medicines; American Cancer Society; Society for Immunotherapy of Cancer; Boehringer Ingelheim; AbbVie; Massachusetts Institute of Technology; Takeda Pharmaceutical Company; Broad Institute; Sanofi; GlaxoSmithKline; Spectrum Pharmaceuticals; Merck; AstraZeneca; Canadian Asian Studies Association; Daiichi Sankyo Europe; National Cancer Institute; Foghorn Therapeutics; Bristol-Myers Squibb; Ignyta; Eli Lilly and Company; American Society of Clinical Oncology; Dana-Farber Cancer Institute; Pfizer; Conquer Cancer Foundation","keywords":"Medicine; Mutant; Adenocarcinoma; Mutation; Cancer research; Resistance (ecology); Lung; Oncology; Internal medicine; Genetics; Cancer; Gene; Biology; Ecology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005175885,0.000110009,0.0003926243,0.0003697534,0.0001650051,0.000007843737,0.0001059766,0.00004992701,0.0002993862],"category_scores_gemma":[0.0001301332,0.000096672,0.0001331464,0.0003936618,0.0000680942,0.0001181335,0.00004320744,0.0004857385,0.00000704505],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004022929,"about_ca_system_score_gemma":0.001360801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003583543,"about_ca_topic_score_gemma":0.0001038728,"domain_scores_codex":[0.998385,0.0002737893,0.0006242525,0.0001573942,0.0003397407,0.0002198669],"domain_scores_gemma":[0.9989359,0.0001700768,0.0004337268,0.0001325603,0.0002031423,0.0001245714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01172164,0.01086192,0.5520606,0.00122725,0.00308393,0.02025059,0.05331977,0.01126417,0.01934023,0.008381523,0.04299052,0.2654979],"study_design_scores_gemma":[0.009764201,0.006687005,0.7345921,0.0003934206,0.002643064,0.005369613,0.01944155,0.001133053,0.0005177859,0.002929808,0.2160815,0.0004468276],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722733,0.01035189,0.001194611,0.01041057,0.001464515,0.0004916187,0.00008590204,0.00001685263,0.003710697],"genre_scores_gemma":[0.9970117,0.00005526298,0.0008106755,0.0002101645,0.0001130816,0.00005359422,0.00002323293,0.00001197606,0.001710337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.265051,"threshold_uncertainty_score":0.9998004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02766883821257422,"score_gpt":0.4252409717940304,"score_spread":0.3975721335814562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}