{"id":"W4220880414","doi":"10.15252/embr.201948754","title":"The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1","year":2022,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; University of Sheffield; Royal Society of Canada; Royal Society; Parkinson's UK; UK Research and Innovation","keywords":"FIS1; Mitophagy; SUMO protein; Cell biology; Mitochondrion; Ubiquitin ligase; Mitochondrial fission; MFN2; Biology; Ubiquitin; Autophagy; Chemistry; mitochondrial fusion; Biochemistry; Apoptosis; Mitochondrial DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003462643,0.0001653869,0.0001506303,0.00002682635,0.0005900336,0.00003582369,0.0001661012,0.0001170432,0.0005471748],"category_scores_gemma":[0.0004404593,0.0001325921,0.0001241588,0.0001198377,0.00009159978,0.000002916359,0.0002216702,0.0002015241,0.0000158827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002325673,"about_ca_system_score_gemma":0.000149388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003774832,"about_ca_topic_score_gemma":0.00001717508,"domain_scores_codex":[0.9982826,0.0002655439,0.0003880054,0.0004938063,0.0002649582,0.0003051012],"domain_scores_gemma":[0.998889,0.00003647289,0.0002413067,0.0006582222,0.00006292117,0.0001120808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001477764,0.00004530436,0.0003661528,0.000002714439,0.00003087021,0.0001696916,0.00003010921,0.00003524548,0.6685003,0.00002726563,0.3303307,0.000313868],"study_design_scores_gemma":[0.0003152289,0.0002322309,0.000141206,0.000001223527,0.00001258943,0.0007443521,0.00005078865,0.00002358215,0.1307896,0.0001703232,0.8673576,0.0001612492],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798569,0.00222099,0.0004110523,0.001894846,0.009275372,0.001244398,0.0001079464,0.0001110768,0.004877406],"genre_scores_gemma":[0.8836188,0.0001386174,0.0006059899,0.002196879,0.002476278,0.001211139,0.003200307,0.0001098413,0.1064421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5377107,"threshold_uncertainty_score":0.599118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005995034843365711,"score_gpt":0.2213224290660764,"score_spread":0.2153273942227107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}