{"id":"W4220880414","doi":"10.15252/embr.201948754","title":"The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1","year":2022,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; University of Sheffield; Royal Society of Canada; Royal Society; Parkinson's UK; UK Research and Innovation","keywords":"FIS1; Mitophagy; SUMO protein; Cell biology; Mitochondrion; Ubiquitin ligase; Mitochondrial fission; MFN2; Biology; Ubiquitin; Autophagy; Chemistry; mitochondrial fusion; Biochemistry; Apoptosis; Mitochondrial DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107187,0.000329868,0.0001695507,0.0001510699,0.0002161296,0.0002410514,0.0001564538,0.0002162802,0.0008412881],"category_scores_gemma":[0.00009543357,0.0001252919,0.0002107255,0.0001102275,0.0002842785,0.0001547976,0.000234037,0.0003321999,0.0003626179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003720438,"about_ca_system_score_gemma":0.0001692559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007794407,"about_ca_topic_score_gemma":0.001264534,"domain_scores_codex":[0.9999441,0.00001207076,0.000004786629,0.00001258543,0.00001202979,0.00001439497],"domain_scores_gemma":[0.9999233,0.000008942739,0.00002546544,0.000005684351,0.000009465037,0.0000271011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403476,0.000006588667,0.000245451,0.00001293179,0.000002613939,0.00006972794,0.000008636276,0.00006691706,0.9990135,0.00005412988,0.00002385166,0.0003552669],"study_design_scores_gemma":[0.00002550427,0.00008602614,0.01909532,0.000004955166,0.00001118771,0.0003155122,0.00004745331,0.001985468,0.977143,0.0001346251,0.001144041,0.000006871267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972041,0.0006933528,0.001165112,0.00008829599,0.000008984511,0.000007554225,0.0001843517,0.00005675852,0.0005914791],"genre_scores_gemma":[0.9984067,0.0002749133,0.0005237721,0.0000248762,0.000002225995,0.000007404637,0.0001454296,0.00001014713,0.0006044526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008412881,"threshold_uncertainty_score":0.002814412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005995034843365711,"score_gpt":0.2213224290660764,"score_spread":0.2153273942227107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}