{"id":"W4220881379","doi":"10.1016/j.cllc.2022.03.002","title":"Safety of Tepotinib in Patients With MET Exon 14 Skipping NSCLC and Recommendations for Management","year":2022,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Cilag; National Cancer Institute; Chugai Pharmaceutical; EMD Serono; Samsung; Genentech; Ipsen; Ono Pharmaceutical; Servier; Les Laboratories Pierre Fabre; Taiho Pharmaceutical; Regeneron Pharmaceuticals; Teva Pharmaceutical Industries; Yuhan; Merck KGaA; Daiichi Sankyo Europe; Sanofi; Amgen; Pfizer; Celgene; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Nausea; Vomiting; Hypoalbuminemia; Internal medicine; Pleural effusion; Adverse effect; Discontinuation; Gastroenterology; Tolerability; Creatinine; Diarrhea","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002422327,0.00007460484,0.0002444685,0.00007104666,0.00008351249,0.000004030132,0.00004142942,0.00002326265,0.0001948628],"category_scores_gemma":[0.00002860894,0.00006256237,0.00005263836,0.0001623872,0.00003804305,0.00003854249,0.00005685269,0.0001131497,2.111464e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001996732,"about_ca_system_score_gemma":0.00008468877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003948902,"about_ca_topic_score_gemma":0.0000402129,"domain_scores_codex":[0.9990591,0.00004275812,0.0004040885,0.0002314858,0.0001363363,0.000126263],"domain_scores_gemma":[0.9994341,0.0001655031,0.0001346114,0.0001472833,0.00005997591,0.00005849179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00137636,0.0006844447,0.8613342,0.0001316188,0.0005433395,0.000002826524,0.0002699771,0.00008500643,6.936784e-7,0.0006108324,0.004243493,0.1307172],"study_design_scores_gemma":[0.01409774,0.0009836667,0.9413054,0.0002415711,0.0007142881,4.800605e-7,0.0002897858,0.0001243573,0.00000274801,0.00006903679,0.0420745,0.0000964125],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813508,0.000976427,0.0008051997,0.006123932,0.0009202108,0.004863087,0.0006981164,0.00003919939,0.004223061],"genre_scores_gemma":[0.9920257,0.0002078171,0.004824243,0.0008745496,0.00004870869,0.0008596572,0.0002509112,0.00001916553,0.0008893011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1306208,"threshold_uncertainty_score":0.2551219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745209117655718,"score_gpt":0.4104270657523426,"score_spread":0.3829749745757854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}