{"id":"W4220883910","doi":"10.1111/bdi.13208","title":"Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative","year":2022,"lang":"en","type":"article","venue":"Bipolar Disorders","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Instituto de Salud Carlos III; National Center for Advancing Translational Sciences; Medical Research Council; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; National Institutes of Health; Norges Forskningsråd; Ministerio de Ciencia e Innovación; National Health and Medical Research Council; Novartis Stiftung für Medizinisch-Biologische Forschung; Eisai; Novartis Foundation; Deakin University; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut National de la Santé et de la Recherche Médicale; Michael Smith Health Research BC; Spier Family Foundation; J. Willard and Alice S. Marriott Foundation; Mayo Foundation for Medical Education and Research; International Society for Bipolar Disorders; NIH Clinical Center; Agence Nationale de la Recherche; Rogers Family Foundation; Wellcome Trust; National Institute of Mental Health; Horizon 2020 Framework Programme; Patient-Centered Outcomes Research Institute; Eli Lilly and Company; Centro de Investigación Biomédica en Red de Salud Mental; Richard Tam Foundation; National Alliance for Research on Schizophrenia and Depression; Victoria General Hospital Foundation; Generalitat de Catalunya; National Institute for Health and Care Research; National Science Foundation; Massachusetts General Hospital; Biogen; Centres de Recerca de Catalunya; European Regional Development Fund; Brain Research Foundation","keywords":"Bipolar disorder; Mood; Logistic regression; Major depressive disorder; Cohort; Psychology; Clinical psychology; Cohort study; Psychiatry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006690785,0.0006236497,0.0009133711,0.0001969922,0.0006302511,0.00004980487,0.0004418226,0.0002157853,0.0008341604],"category_scores_gemma":[0.0001501359,0.0005114008,0.0003127381,0.001426031,0.0004837531,0.0002047469,0.0003588472,0.0006354879,0.00003130787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008178822,"about_ca_system_score_gemma":0.0007809472,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.04365314,"about_ca_topic_score_gemma":0.02644517,"domain_scores_codex":[0.9949547,0.0005867771,0.001103471,0.001041063,0.0016095,0.0007044768],"domain_scores_gemma":[0.9977108,0.0004272121,0.0004740172,0.000972329,0.0001627206,0.0002529859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00215731,0.00199768,0.9755276,0.00002095506,0.00157294,0.000008664457,0.00242683,0.0004527721,0.00009713943,0.00009984242,0.006968234,0.00867],"study_design_scores_gemma":[0.004970446,0.0005656174,0.5316184,0.00002553578,0.0003955387,0.000006046993,0.002489589,0.0001828501,0.0000652974,0.0003135659,0.4590859,0.000281276],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6315103,0.3322216,0.0001431662,0.002762073,0.0006717467,0.002350039,0.03000377,0.000121336,0.0002160438],"genre_scores_gemma":[0.9674823,0.02272071,0.00008023585,0.0003419347,0.0001091905,0.0005328341,0.008444862,0.00007855875,0.0002094254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4521177,"threshold_uncertainty_score":0.9997337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004840771223149702,"score_gpt":0.2170283617834775,"score_spread":0.2121875905603278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}