{"id":"W4220884345","doi":"10.1158/1538-7445.sabcs21-p5-16-11","title":"Abstract P5-16-11: Ipatasertib (ipat) in combination with palbociclib (palbo) and fulvestrant (fulv) in patients (pts) with hormone receptor-positive (HR+) HER2-negative advanced breast cancer (aBC)","year":2022,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Palbociclib; Medicine; Breast cancer; Fulvestrant; Internal medicine; Cancer; Oncology; Aromatase inhibitor; Tamoxifen; Pharmacology; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005105148,0.0006665635,0.0009993003,0.0003691683,0.0002416734,0.0006383258,0.000544365,0.0005133388,0.00372208],"category_scores_gemma":[0.0004776469,0.0002869838,0.0007659197,0.0004299058,0.0005634385,0.0005359731,0.0003373152,0.001995225,0.0007725786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009345079,"about_ca_system_score_gemma":0.001039936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008556096,"about_ca_topic_score_gemma":0.002135205,"domain_scores_codex":[0.9997708,0.00007492822,0.00001615978,0.00005051668,0.00003200107,0.00005548992],"domain_scores_gemma":[0.9997343,0.0000401377,0.00005273079,0.00001899087,0.00001339657,0.0001404574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6227546,0.04657521,0.01986561,0.0009784291,0.001110058,0.0008690038,0.0002835628,0.004841537,0.07931142,0.0003661779,0.004995476,0.2180489],"study_design_scores_gemma":[0.2273715,0.6856576,0.05785478,0.00006749463,0.0008212826,0.001209921,0.0001204101,0.00373553,0.01652841,0.0002370036,0.006345101,0.00005094509],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947179,0.001023165,0.0002943911,0.0001955092,0.00003974913,0.0006890153,0.0008891139,0.00004648403,0.002104712],"genre_scores_gemma":[0.9950228,0.0005649352,0.0006260155,0.0002035669,0.0000584967,0.0004915022,0.001545886,0.0000117458,0.001475083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00372208,"threshold_uncertainty_score":0.01245159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0217633982836299,"score_gpt":0.333341173949691,"score_spread":0.3115777756660611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}