{"id":"W4220884427","doi":"10.15252/emmm.202114990","title":"CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia","year":2022,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer; Institute of Infection and Immunity","funders":"Universitätsklinikum Heidelberg; Deutsche Krebshilfe; Deutsche Forschungsgemeinschaft","keywords":"Myeloid leukemia; Wnt signaling pathway; Biology; Cancer research; Leukemia; Venetoclax; Stem cell; Cell biology; Immunology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001230338,0.0002763428,0.000305741,0.0002367163,0.0001293174,0.0002640173,0.0002716043,0.0001514715,0.001608184],"category_scores_gemma":[0.0001040928,0.00008169006,0.0001562309,0.0001768207,0.0002157218,0.0001452329,0.000169321,0.0006003572,0.0002545565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002658919,"about_ca_system_score_gemma":0.0003090084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005650651,"about_ca_topic_score_gemma":0.002024033,"domain_scores_codex":[0.9999303,0.00001451604,0.000005883173,0.00000894821,0.00001430145,0.00002611062],"domain_scores_gemma":[0.9999474,0.00001052314,0.000009998914,0.000006465741,0.000003033569,0.00002262077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006353211,0.001484126,0.001259993,0.0002445973,0.00005884067,0.000204116,0.00005174888,0.001726714,0.943219,0.000953353,0.001288624,0.04315565],"study_design_scores_gemma":[0.001382079,0.0123257,0.01545803,0.00002450225,0.0001134791,0.000683186,0.00007786296,0.00587646,0.9513242,0.0003100403,0.01240662,0.00001786261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942531,0.001657283,0.0006898837,0.0001344457,0.00005542423,0.00008847834,0.0002491579,0.0001622572,0.002709968],"genre_scores_gemma":[0.9972031,0.0007037492,0.0005774148,0.00003070897,0.00001181067,0.00004911305,0.0002323236,0.000007784833,0.00118398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608184,"threshold_uncertainty_score":0.005379915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01058777940480965,"score_gpt":0.2508758020064831,"score_spread":0.2402880226016735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}