{"id":"W4220885972","doi":"10.1016/j.ymgme.2022.01.096","title":"THE MECHANISM OF CREATINE MEDIATED DOWNREGULATION OF AGAT EXPRESSION","year":2022,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Genetics and Physical Performance","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Downregulation and upregulation; Mechanism (biology); Creatine; Cell biology; Chemistry; Medicine; Internal medicine; Biology; Biochemistry; Physics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002070208,0.0001101013,0.0001481566,0.00002810442,0.000150579,0.000007687362,0.0001807061,0.00004503328,0.00001003362],"category_scores_gemma":[0.00002454865,0.00008686841,0.00007201672,0.0001010743,0.00008591163,0.000001158243,0.0002958213,0.00006602957,2.356534e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002015317,"about_ca_system_score_gemma":0.00003041046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007680871,"about_ca_topic_score_gemma":0.000001473638,"domain_scores_codex":[0.9990916,0.00009003515,0.0002432149,0.0001881702,0.0002434009,0.0001436288],"domain_scores_gemma":[0.9993571,0.00001439474,0.0001613601,0.0003270734,0.00008881973,0.00005127128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000395448,0.00003545542,0.00005003716,0.0000087395,0.00002610866,3.108679e-7,0.00004198345,0.0007804715,0.9941706,0.003123482,0.00006360593,0.001659656],"study_design_scores_gemma":[0.0004338306,0.0001741578,0.003927353,0.00000283164,0.00003230116,0.00000317939,0.00003717051,0.001215572,0.9631475,0.002058377,0.02885969,0.0001080056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878551,0.009176249,0.002373076,0.00007554032,0.00009040095,0.0001589315,0.0000447804,0.00000243447,0.0002234952],"genre_scores_gemma":[0.9975736,0.001316391,0.0008040115,0.00007455351,0.00003802327,0.00002711022,0.0000736238,0.00001642706,0.0000762271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03102307,"threshold_uncertainty_score":0.3542391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003745097139639286,"score_gpt":0.2027232207988455,"score_spread":0.1989781236592062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}