{"id":"W4220890844","doi":"10.1186/s13195-022-00981-1","title":"Pilot study of repeated blood-brain barrier disruption in patients with mild Alzheimer’s disease with an implantable ultrasound device","year":2022,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institute on Aging; Bpifrance","keywords":"Medicine; Geriatric psychiatry; Neurology; Ultrasound; Disease; Neurosurgery; Neuroradiology; Blood–brain barrier; Internal medicine; Radiology; Psychiatry; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009398001,0.0007414712,0.0008076052,0.0003641399,0.0006064403,0.0003907847,0.0002498575,0.0004999338,0.001015615],"category_scores_gemma":[0.001559404,0.0002397897,0.0005032569,0.00021541,0.0004873879,0.0002923144,0.0002631284,0.000480915,0.0002566286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003489236,"about_ca_system_score_gemma":0.0004171279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010115,"about_ca_topic_score_gemma":0.0009301135,"domain_scores_codex":[0.9995843,0.0001680079,0.00003825252,0.0000905727,0.00005648291,0.00006237961],"domain_scores_gemma":[0.9992923,0.0002052034,0.0001153227,0.00007316899,0.00008682613,0.0002271407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1002019,0.06543013,0.6517061,0.0003902997,0.0005448457,0.01044914,0.003356676,0.0005476159,0.1035084,0.0002330603,0.0005062765,0.06312547],"study_design_scores_gemma":[0.00392878,0.4642418,0.5193209,0.00001534038,0.0002944267,0.003601258,0.0006120714,0.0007761815,0.005888864,0.00008817347,0.00118631,0.00004584975],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995765,0.00008918575,0.00009378712,0.00001001644,0.00000591387,0.00006936486,0.00001765933,0.000002653203,0.0001349194],"genre_scores_gemma":[0.999406,0.00006183346,0.0001850711,0.00003771169,0.00002295336,0.00007156286,0.00005754148,0.000001106698,0.0001563489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001015615,"threshold_uncertainty_score":0.004970193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06501746226846805,"score_gpt":0.3159845446459777,"score_spread":0.2509670823775096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}