{"id":"W4220897135","doi":"10.1101/2022.03.13.484174","title":"<i>In vivo</i> CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University Health Network; University of Toronto; Princess Margaret Cancer Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"University of Toronto; Fondation Brain Canada; McGill University","keywords":"CRISPR; Pancreatic cancer; Cancer research; Biology; In vivo; Mutagenesis; Cancer; Mutation; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000293576,0.0003462505,0.0002561546,0.0002633207,0.0001617019,0.0005069915,0.0002510611,0.0003778628,0.00293719],"category_scores_gemma":[0.000170076,0.0001726423,0.0002784984,0.0001535914,0.0002442752,0.0001721342,0.0003197461,0.0005834375,0.0008511353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003275362,"about_ca_system_score_gemma":0.0001844418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006291464,"about_ca_topic_score_gemma":0.001024373,"domain_scores_codex":[0.999835,0.00002617704,0.00001536441,0.00003893232,0.00005930218,0.00002515118],"domain_scores_gemma":[0.9998778,0.00002925899,0.00003529009,0.00002413969,0.000009915257,0.0000235704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005426017,0.00001404638,0.0004003503,0.00002577318,0.00001024637,0.0001094809,0.00001420509,0.0002915654,0.9949803,0.0006557659,0.0003846359,0.003059493],"study_design_scores_gemma":[0.000008624475,0.00004475777,0.001269433,0.00000425128,0.0000128906,0.0004062882,0.00001167391,0.002161555,0.9884114,0.000208796,0.007456346,0.000004159506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8832288,0.001328225,0.09144995,0.0009630734,0.0001863575,0.0001561006,0.004592295,0.002612251,0.01548292],"genre_scores_gemma":[0.9494256,0.0008421857,0.03345983,0.0003000143,0.00003351234,0.00005797426,0.002904514,0.0004950527,0.01248135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00293719,"threshold_uncertainty_score":0.009825885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02518344887095199,"score_gpt":0.3034544929177696,"score_spread":0.2782710440468176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}