{"id":"W4220900730","doi":"10.1101/2022.03.23.485308","title":"True-to-scale DNA-density maps correlate with major accessibility differences between active and inactive chromatin","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Boehringer Ingelheim Stiftung; Cancer Research Society","keywords":"Chromatin; Macromolecule; DNA; Fluorescence microscope; Microscopy; DNA replication; Biophysics; Molecular biology; Cell biology; Resolution (logic); Transcription (linguistics); Chemistry; Fluorescence; Biology; Physics; Genetics; Optics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001274035,0.0001362181,0.0001375705,0.0004762307,0.0001216988,0.0004374293,0.0001726486,0.0001809356,0.002076648],"category_scores_gemma":[0.00030049,0.0001712321,0.0000847063,0.0001969432,0.0003184914,0.0003066045,0.0002560882,0.0003093949,0.0003623349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001983924,"about_ca_system_score_gemma":0.0000647444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005949448,"about_ca_topic_score_gemma":0.0007933371,"domain_scores_codex":[0.9999323,0.000006955256,0.000002843363,0.00003000202,0.00001584015,0.00001200112],"domain_scores_gemma":[0.9997519,0.0001021044,0.00005689632,0.00002530214,0.00003176545,0.00003210647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009723182,0.00000682866,0.00459674,0.00004773695,0.00001077507,0.00005632995,0.00008304608,0.0004626512,0.9912442,0.000507508,0.00006867063,0.002818334],"study_design_scores_gemma":[0.00001343562,0.0000794948,0.2113536,0.00001313398,0.00002886952,0.0007538086,0.0002539676,0.007573745,0.7760091,0.001541542,0.002360731,0.0000186226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835712,0.0006381936,0.01363948,0.00005478397,0.000004315356,0.000005304219,0.0003330729,0.0001509605,0.001602723],"genre_scores_gemma":[0.9964123,0.0001296719,0.00267403,0.00001403454,0.000003645861,0.000007942632,0.000226597,0.00001969562,0.0005119177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002076648,"threshold_uncertainty_score":0.0069471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007725667515890416,"score_gpt":0.2111184866624947,"score_spread":0.2033928191466043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}