{"id":"W4220904165","doi":"10.1182/blood.2021015365","title":"Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Proinflammatory cytokine; NADPH oxidase; Inflammation; TLR4; Immunology; TLR2; Chronic granulomatous disease; Macrophage; Alveolar macrophage; Biology; Chemistry; Cell biology; Reactive oxygen species; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005023954,0.0007749238,0.0005258707,0.001326371,0.0006141856,0.0008960898,0.0007830141,0.001248401,0.002971067],"category_scores_gemma":[0.0002646705,0.0005580736,0.0007017841,0.0003496069,0.0008236078,0.0006271794,0.0007410203,0.002058107,0.001513456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008419605,"about_ca_system_score_gemma":0.0005799519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008782655,"about_ca_topic_score_gemma":0.001131996,"domain_scores_codex":[0.9991966,0.00008770592,0.00008313695,0.0002532888,0.0001990164,0.0001802412],"domain_scores_gemma":[0.9995331,0.00002692547,0.0001532857,0.00007340156,0.00004494116,0.000168478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006131086,0.0002403338,0.0005742716,0.00007842548,0.0000191806,0.0002045799,0.00007171809,0.0001218898,0.993863,0.0007415719,0.0003169337,0.003155072],"study_design_scores_gemma":[0.0004009325,0.001916346,0.01387999,0.000109939,0.00014803,0.002821853,0.0002352651,0.003395563,0.9456339,0.001045878,0.03036087,0.00005138512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596599,0.004128622,0.02226576,0.001035084,0.0003169619,0.0003385191,0.005316988,0.0012467,0.005691387],"genre_scores_gemma":[0.9561111,0.002875975,0.01423115,0.0006921878,0.0001225397,0.0009140147,0.005225538,0.0004962535,0.01933119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002971067,"threshold_uncertainty_score":0.009939134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009239000233799506,"score_gpt":0.2137982529060934,"score_spread":0.2045592526722939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}