{"id":"W4220905288","doi":"10.1016/j.actbio.2022.02.043","title":"Design and development of Branched Poly(ß-aminoester) nanoparticles for Interleukin-10 gene delivery in a mouse model of atherosclerosis","year":2022,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Inflammation; Gene delivery; In vivo; Genetic enhancement; Medicine; Immunology; Chemistry; Molecular biology; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003257475,0.0005980902,0.0003348888,0.0004000089,0.000175434,0.0003342247,0.0004457658,0.0009933984,0.0008458235],"category_scores_gemma":[0.0001410829,0.0003914681,0.000396307,0.0001623222,0.0003060685,0.0003786233,0.0001832483,0.001027138,0.0005406639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003572857,"about_ca_system_score_gemma":0.0002739776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004817388,"about_ca_topic_score_gemma":0.0005248597,"domain_scores_codex":[0.9997916,0.00002734915,0.0000270796,0.00005455808,0.00005527041,0.00004424126],"domain_scores_gemma":[0.9998252,0.00002320232,0.00005602351,0.00001511215,0.00002467282,0.00005581793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001086049,0.00008456284,0.0000332505,0.00003826613,0.000004974928,0.00003797892,0.00001222041,0.0001750708,0.9981439,0.0001323268,0.00003335617,0.00119552],"study_design_scores_gemma":[0.00009408755,0.0009328896,0.000487011,0.00001119019,0.00002755653,0.0001428219,0.000009106741,0.001541478,0.9930513,0.00007123542,0.003621327,0.00001001087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9234576,0.003307782,0.0652713,0.000647297,0.0003386198,0.0009653273,0.001187921,0.0006476702,0.004176445],"genre_scores_gemma":[0.90426,0.004372623,0.07547966,0.0003785675,0.00006182327,0.001428208,0.00115985,0.0001579973,0.01270111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009933984,"threshold_uncertainty_score":0.002829552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03885413337581533,"score_gpt":0.2439761972677874,"score_spread":0.205122063891972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}