{"id":"W4220906332","doi":"10.1016/j.jconrel.2022.03.004","title":"DMPC/Chol liposomal copper CX5461 is therapeutically superior to a DSPC/Chol formulation","year":2022,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; BC Innovation Council; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Liposome; Chemistry; Copper; Solubility; Combinatorial chemistry; Dosage form; Pharmacokinetics; Biophysics; Chromatography; Pharmacology; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003966652,0.0001710137,0.0003627,0.0001719445,0.0002015498,0.00005823167,0.0003303704,0.00009902841,0.0005335589],"category_scores_gemma":[0.0001372723,0.0001385438,0.0004158634,0.0001108675,0.00001925696,0.00001441116,0.00009155426,0.0002826201,0.00003437805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005953516,"about_ca_system_score_gemma":0.0003490878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000349847,"about_ca_topic_score_gemma":0.00002684024,"domain_scores_codex":[0.9984512,0.0001463381,0.0005546213,0.0002022604,0.000360553,0.0002850474],"domain_scores_gemma":[0.9988816,0.00002717202,0.0002118568,0.0002483858,0.0003590162,0.0002719068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0144369,0.0002733658,0.001015896,0.000006843423,0.0005162651,0.00008311088,0.0003432976,0.001204847,0.9570876,0.00007000987,0.0163848,0.008577053],"study_design_scores_gemma":[0.05768707,0.01982132,0.006110876,0.00009562154,0.0007408611,0.001414282,0.001413336,0.003699626,0.17452,0.0004831642,0.7326549,0.00135896],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933048,0.001388475,0.0005506621,0.003054617,0.0003938859,0.0003772041,0.00002603786,0.000004487521,0.0008997916],"genre_scores_gemma":[0.9896462,0.000139996,0.0001958672,0.00795559,0.0004495194,0.00003636082,0.000009836657,0.00002288733,0.001543743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7825676,"threshold_uncertainty_score":0.5842096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009378675172528498,"score_gpt":0.2586064329773153,"score_spread":0.2492277578047868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}