{"id":"W4220907252","doi":"10.1136/bmj-2021-069761","title":"Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study","year":2022,"lang":"en","type":"article","venue":"BMJ","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":681,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Pharmaceuticals; National Center for Advancing Translational Sciences; Agency for Toxic Substances and Disease Registry; National Institute of Allergy and Infectious Diseases; Centers for Disease Control and Prevention; Regeneron Pharmaceuticals; National Institutes of Health; Pfizer; Incyte; York University; Vanderbilt University Medical Center; University of Oxford; Vanderbilt University; Intermountain Research and Medical Foundation; Marcus Foundation; Cincinnati Children's Hospital Medical Center; National Institute of General Medical Sciences; United Therapeutics Corporation; Medpace; Brigham Young University; Gilead Sciences; Agency for Healthcare Research and Quality; Sanofi; U.S. Department of Defense; Abbott Laboratories; National Heart, Lung, and Blood Institute","keywords":"Medicine; Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Odds ratio; Confidence interval; Observational study; Internal medicine; 2019-20 coronavirus outbreak; Virology; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001237098,0.0003605797,0.0003896553,0.0004633203,0.0002911754,0.0004688762,0.0003563155,0.0005381033,0.000646784],"category_scores_gemma":[0.004010046,0.0003403802,0.0005974604,0.0007242737,0.0002904697,0.0004152325,0.0003322433,0.0005985202,0.000115117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003488636,"about_ca_system_score_gemma":0.0003328888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004854723,"about_ca_topic_score_gemma":0.005550209,"domain_scores_codex":[0.9988279,0.00039171,0.0001789054,0.000293071,0.0001891908,0.0001191973],"domain_scores_gemma":[0.9958313,0.0006547105,0.002590357,0.0002081566,0.0002835842,0.0004319073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001638323,0.00004134708,0.9991269,0.000008956912,0.00006952428,0.0000181436,0.00001334066,0.00003062891,0.00005712708,0.000004826379,0.0000721641,0.0003932007],"study_design_scores_gemma":[0.00002286115,0.0002306428,0.9993021,0.000008250454,0.00003505646,0.0001191795,0.00005310554,0.0001213884,0.0000320375,0.000006373816,0.00006645572,0.000002509393],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990226,0.0002815652,0.00004861186,0.00002815562,0.000005391411,0.00001158731,0.0004328392,0.000001703244,0.0001675944],"genre_scores_gemma":[0.9991134,0.0001143726,0.00005168828,0.00003688686,0.000008977931,0.0000111897,0.0006315548,8.251914e-7,0.00003109271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004854723,"threshold_uncertainty_score":0.009652913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1417907778579062,"score_gpt":0.4458875981418364,"score_spread":0.3040968202839302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}