{"id":"W4220909053","doi":"10.1038/s41586-022-04508-4","title":"Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":442,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal","funders":"National Cancer Institute; Ono Pharmaceutical; Bristol-Myers Squibb","keywords":"Nivolumab; Medicine; Ipilimumab; Hazard ratio; Internal medicine; Chemotherapy; Oncology; Cancer; Gastroenterology; Randomized controlled trial; Immunotherapy; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003142393,0.0002886064,0.0006538286,0.0001911987,0.000201394,0.0003598033,0.0003028408,0.0005332557,0.001314664],"category_scores_gemma":[0.0002540154,0.0001104116,0.0004781493,0.0002256901,0.0002752545,0.0002125357,0.0002249333,0.0008540376,0.0003424653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007207831,"about_ca_system_score_gemma":0.0006334936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001131206,"about_ca_topic_score_gemma":0.002049634,"domain_scores_codex":[0.999882,0.00004491391,0.00001246615,0.00002224452,0.00001417455,0.00002410988],"domain_scores_gemma":[0.9999011,0.00002444,0.00001514106,0.00001003678,0.000007026581,0.00004225888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2452798,0.01431323,0.01722488,0.00293187,0.001174686,0.001472913,0.0001871736,0.003122381,0.1766715,0.0004984502,0.00841642,0.5287067],"study_design_scores_gemma":[0.09355,0.5158682,0.1665203,0.0004733058,0.002572475,0.004251487,0.0001855096,0.004197744,0.1402692,0.0006065132,0.07141742,0.00008777338],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679088,0.02749089,0.0003211164,0.0004312806,0.0004565029,0.0003644585,0.0003012404,0.00007069555,0.002655129],"genre_scores_gemma":[0.9909208,0.00584859,0.0005446094,0.0004862594,0.0001489928,0.0001637758,0.0004681083,0.000008276392,0.001410672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001314664,"threshold_uncertainty_score":0.005229652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01058143885385141,"score_gpt":0.3003839206273684,"score_spread":0.289802481773517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}