{"id":"W4220909641","doi":"10.1111/ene.15331","title":"Cathepsin D as biomarker in cerebrospinal fluid of nusinersen‐treated patients with spinal muscular atrophy","year":2022,"lang":"en","type":"article","venue":"European Journal of Neurology","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Canadian Institutes of Health Research; Albert-Ludwigs-Universität Freiburg; Bundesministerium für Bildung und Forschung; H2020 European Research Council; Canada Research Chairs; Deutsche Forschungsgemeinschaft; Muscular Dystrophy Canada; Canada Foundation for Innovation; Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen; French Muscular Dystrophy Association","keywords":"SMA*; Spinal muscular atrophy; Biomarker; Cerebrospinal fluid; Medicine; Cathepsin; Cathepsin D; Cohort; Internal medicine; Atrophy; Gastroenterology; Western blot; Pathology; Oncology; Biology; Biochemistry; Enzyme; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000368048,0.0003340849,0.0005094111,0.0005119636,0.0003118912,0.000450661,0.0001728794,0.0004299925,0.0004757976],"category_scores_gemma":[0.0009340134,0.0001048235,0.00026128,0.0003093247,0.0002220758,0.0002091184,0.0002204413,0.0002755456,0.00011938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002659466,"about_ca_system_score_gemma":0.0001868531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008600939,"about_ca_topic_score_gemma":0.0009860815,"domain_scores_codex":[0.9997997,0.00004746088,0.00003892096,0.00005082407,0.00003857089,0.00002446705],"domain_scores_gemma":[0.9994916,0.00009626766,0.0002250542,0.00002282895,0.0000887631,0.00007547515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0016347,0.00008814016,0.9662496,0.0001059579,0.0001325052,0.001309041,0.000266747,0.0001226447,0.02212078,0.0000161639,0.0001551176,0.007798607],"study_design_scores_gemma":[0.00002750132,0.001243647,0.9894724,0.00002779592,0.0001040724,0.003826362,0.0002801534,0.0003390024,0.004155212,0.00002683691,0.0004878064,0.00000906312],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998892,0.0008036627,0.00005988714,0.00001780088,0.000004360779,0.000005021601,0.00008298132,0.000004231835,0.0001300534],"genre_scores_gemma":[0.9993501,0.0002382574,0.0001605395,0.0000279578,0.000005517474,0.000005498621,0.0001458024,0.000001053027,0.00006525122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008600939,"threshold_uncertainty_score":0.001946449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321209182749716,"score_gpt":0.2526514984131473,"score_spread":0.2394394065856501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}