{"id":"W4220912787","doi":"10.3389/fcimb.2022.764711","title":"SAGA Complex Subunits in Candida albicans Differentially Regulate Filamentation, Invasiveness, and Biofilm Formation","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Sciences and Engineering Research Council of Canada; Concordia University; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Candida albicans; Mutant; Cell biology; Schizosaccharomyces; Fungal protein; Acetyltransferase; Downregulation and upregulation; Histone acetyltransferase; Schizosaccharomyces pombe; Gene; Transcription factor; Genetics; Acetylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004440319,0.0002891088,0.0001155875,0.0002495802,0.0001506486,0.0002916847,0.000193422,0.0002140775,0.0008832369],"category_scores_gemma":[0.00007258036,0.0001909375,0.0002494688,0.0001790374,0.000144115,0.0001069168,0.0002057465,0.0004013291,0.0003525176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003168822,"about_ca_system_score_gemma":0.0001746066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001466551,"about_ca_topic_score_gemma":0.002025449,"domain_scores_codex":[0.9998876,0.000007015492,0.00001039234,0.00002407262,0.00004682741,0.00002409954],"domain_scores_gemma":[0.9999118,0.000006212972,0.0000269246,0.000008920465,0.00001928221,0.00002682559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004311979,0.000006359368,0.0002984063,0.00001043452,0.000003194098,0.00003073373,0.000006269451,0.00002484788,0.9990834,0.00002845139,0.00003452647,0.0004302874],"study_design_scores_gemma":[0.00001676264,0.00009494526,0.05165782,0.00001399334,0.00003611601,0.0004329856,0.000108475,0.001563083,0.9428928,0.0001136096,0.003059029,0.00001046689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960107,0.001222687,0.0008239577,0.0000768173,0.00002316822,0.000009328794,0.0008691588,0.00006603184,0.0008982699],"genre_scores_gemma":[0.9950641,0.0003809714,0.0008925541,0.00005478018,0.000004709051,0.00001797788,0.001333715,0.00002967556,0.002221498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466551,"threshold_uncertainty_score":0.002954781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01704800885693705,"score_gpt":0.2323941066684107,"score_spread":0.2153460978114737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}