{"id":"W4220914022","doi":"10.1101/2022.03.03.482848","title":"SUMOylation of ABCD3 restricts bile acid synthesis and regulates metabolic homeostasis","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Ottawa; Montreal Neurological Institute and Hospital; University of Toronto; University Health Network; McGill University; Princess Margaret Cancer Centre","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; McGill University","keywords":"Ubiquitin ligase; Bile acid; SUMO protein; Biology; Peroxisome; Cell biology; G protein-coupled bile acid receptor; Biochemistry; Ubiquitin; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001699706,0.0002472536,0.0002479221,0.0002553183,0.0002600223,0.0005370257,0.000202754,0.0003385178,0.002548945],"category_scores_gemma":[0.0001634212,0.0001797378,0.0002195651,0.0001893202,0.0003550009,0.0002294717,0.0004416918,0.0005096955,0.001268122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004899246,"about_ca_system_score_gemma":0.0002063749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004488734,"about_ca_topic_score_gemma":0.0008694759,"domain_scores_codex":[0.9998148,0.00001874845,0.00001370314,0.00004315514,0.00006619396,0.00004342493],"domain_scores_gemma":[0.9998735,0.00001422806,0.00003659043,0.00002300669,0.00001672901,0.00003589986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008878671,0.000005886146,0.0005363754,0.00002038195,0.000003851043,0.00005661362,0.000006508291,0.00006835962,0.997684,0.0002729276,0.0001729333,0.001083255],"study_design_scores_gemma":[0.00002112265,0.00002952133,0.005483273,0.000004722544,0.000008293122,0.0002718942,0.0000323022,0.001934438,0.9861472,0.0002471173,0.005815303,0.000004598199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755976,0.002261127,0.01362286,0.001020507,0.0001462524,0.00001852131,0.001934357,0.0004052021,0.004993508],"genre_scores_gemma":[0.9909821,0.0005645643,0.002215442,0.0001381606,0.00001463041,0.00001530562,0.0007951843,0.0001088796,0.005165716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002548945,"threshold_uncertainty_score":0.00852704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01031935515944866,"score_gpt":0.2156556984951868,"score_spread":0.2053363433357382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}